Abstract P141 Table 1

Adverse pregnancy outcome ratio according to the achievement of remission at conception

Zen/Doria remission Logistic regression model
(univariate analysis)
Logistic regression model
(multivariate analysis)
Factor no remission remission p-value OR 95%CI P value aOR 95% CI P value
N 37 59
Overall APO (%) 26 (70.3) 23 (39.0) <0.01 0.27 0.11– 0.65 <0.01 0.28 0.11– 0.70 <0.01
Maternal APO (%) 15 (40.5) 11 (18.6) 0.032 0.34 0.13– 0.85 0.021 0.33 0.12– 090 0.030
Neonatal APO (%) 23 (62.2) 23 (39.0) 0.036 0.39 0.17– 0.90 0.028 0.37 0.15– 0.90 0.029
PROMISSE APO (%) 10 (27.0) 12 (20.3) 0.47 0.69 0.26–1.81 0.45 0.64 0.23–1.76 0.38
Flare during pregnancy (%) 8 (21.6) 2 (3.4) 0.012 0.13 0.03– 0.64 0.012
Flare after delivery (%) 2 (6.7) 1 (1.9) 0.29 0.26 0.23–3.04 0.29
Gestational DM (%) 6 (16.2) 4 (6.8) 0.18 0.38 0.10–1.43 0.15
Preeclampsia (%) 3 (8.1) 3 (5.1) 0.67 0.61 0.12–3.18 0.56
Hypertensive disorders in pregnancy (%) 7 (18.9) 6 (10.2) 0.24 0.49 0.15–1.58 0.23
HELLP syndrome (%) 1 (2.7) 1 (1.7) 1.0 0.62 0.04–10.2 0.74
Oligohydramnios (%) 6 (16.2) 2 (3.4) 0.053 0.19 0.04– 0.97 0.046
Maternal death (%) 0 (0.0) 0 (0.0) NA NA NA NA
Live birth (%)&x203B; 29 (78.4) 54 (91.5) 0.12 2.98 0.89–9.94 0.76
Total duration of gestation (days) 262.0 [242.0 , 271.0] 268.0 [262.0 , 276.0] 0.019 NA NA NA
Preterm birth (%) 6 (18.2) 8 (14.8) 0.77 0.78 0.25–2.5 0.67
Spontaneous abortion (%) 1 (2.8) 2 (3.4) 1.0 1.25 0.11–14.3 0.86
Missed abortion (%) 3 (8.1) 1 (1.8) 0.30 0.20 0.02–2.02 0.17
Iatrogenic abortion (%) 5 (13.5) 2 (3.4) 0.10 0.23 0.04– 1.22 0.084
Still birth (%) 0 (0.0) 0 (0.0) NA NA NA NA
Height at birth (cm) 46.0 [43.8 , 48.0] 48.0 [46.5 , 49.5] <0.01 NA NA NA
Weight at birth (g) 2472.0 [2202.0 , 2896.0 ] 2716.0 [2476.5 , 3013.8 ] 0.025 NA NA NA
Low birth weight (%) 15 (51.7) 15 (27.8) 0.054 0.36 0.14– 0.92 0.033
SGA (%) 6 (20.7) 8 (14.8) 0.55 0.67 0.21–2.15 0.50
Apgar score (1m) 8.00 [8.00, 8.00] 8.00 [8.00, 8.00] 0.53 NA NA NA
Apgar Score (5m) 9.00 [9.00, 9.00] 9.00 [9.00, 9.00] 0.55 NA NA NA
Apgar.score.1m>7 (%) 27 (93.1) 53 (98.1) 0.28 3.93 0.34–45.3 0.27
Apgar.score.5m>7 (%) 29 (100.0) 54 (100.0) 1.0 NA NA NA
Major malformation 1 (3.4) 1 (1.9) 1.0 0.53 0.32–8.80 0.66
Death of neonate 0 (0.0) 0 (0.0) NA NA NA NA
  • &x203B;multivariate analysis adjusted for renal manifestation, hydroxychloroquine prescription, and aspirin prescription at conception. APO; adverse pregnancy outcome, DM; diabetes mellitus, NA; not applicable, OR; odds ratio, PROMISSE; Predictors of Pregnancy Outcome: Biomarkers in Antiphospholipid Antibody Syndrome and Systemic Lupus Erythematosus, SGA; small for gestational age