Comparison of lupus features and health-related quality of life between patients classified in severe disease activity (SDA) by both SLE-DAS (>9.90) and BILAG-2004 (>11) versus patients classified in SDA only by SLE-DAS or BILAG-2004
| SDA by SLE-DAS and BILAG-2004 | SDA only by SLE-DAS | SDA only by BILAG-2004 | |||
|---|---|---|---|---|---|
| n=149 (34%) | n=55 (12.6%) | p* | n=44 (10%) | p* | |
| SLE manifestations, n (%) | |||||
| - Neuropsychiatric | 4 (2.68) | 1 (1.82) | 1.000 | 0 (0.00) | 0.576 |
| - Systemic vasculitis | 1 (0.67) | 0 (0.00) | 1.000 | 0 (0.00) | 1.000 |
| - Mucocutaneous vasculitis | 30 (20.13) | 8 (14.55) | 0.363 | 5 (11.36) | 0.185 |
| - Cardiopulmonary | 1 (0.67) | 0 (0) | 1.000 | 0 (0.00) | 1.000 |
| - Serositis | 19 (12.75) | 5 (9.09) | 0.471 | 1 (2.27) | 0.049 |
| - Lupus nephritis | 24 (16.11) | 7 (12.73) | 0.551 | 0 (0.00) | 0.002 |
| - Arthritis | 129 (86.58) | 45 (81.82) | 0.394 | 25 (56.82) | <0.0001 |
| - 28-SJC | 4 (2;8) | 3 (1;7) | 0.2668 | 1 (0;2) | <0.0001 |
| - Myositis | 6 (4.03) | 2 (3.64) | 1.000 | 0 (0.00) | 0.340 |
| - Mucocutaneous | 142 (95.30) | 51 (89.09) | 0.117 | 41 (93.18) | 0.698 |
| - Thrombocytopenia | 3 (2.01) | 1 (1.82) | 1.000 | 1 (2.27) | 1.000 |
| - Leukopenia | 13 (8.72) | 5 (9.09) | 1.000 | 4 (9.09) | 1.000 |
| - Hypocomplementemia | 72 (48.32) | 28 (50.91) | 0.743 | 19 (43.18) | 0.548 |
| - Increased anti-dsDNA | 77 (51.68) | 31 (56.36) | 0.552 | 13 (29.55) | 0.01 |
| Severe CLASI-A, n (%) | 9 (6.04) | 0 (0.00) | 0.117 | 2 (4.55) | 1.000 |
| SLEDAI-2K, Median (IQR) | 12 (8;14) | 10 (8;12) | 0.0996 | 8 (6;9) | <0.0001 |
| PtGA, Median (IQR) | 53 (41.5;67) | 50 (26;67) | 0.0388 | 41 (21;59) | 0.0044 |
| FACIT-F, Median (IQR) | 24 (14;32) | 23 (16;35) | 0.5031 | 33 (21;40) | 0.0015 |
| LupusQoL, Median (IQR) | |||||
| - Physical Health | 56.3 (31.3;75) | 50 (31.3;75) | 0.8244 | 68.8 (46.9;81.2) | 0.0210 |
| - Pain | 54.2 (25;75) | 50 (25;75) | 0.7944 | 66.7 (50;75) | 0.0153 |
| - Planning | 58.33 (25;75) | 50 (33.3;75) | 0.7357 | 75 (50;83.3) | 0.0406 |
| - Intimate relationships | 62.5 (25;75) | 50 (25;75) | 0.9453 | 75 (37.5;87.5) | 0.2609 |
| - Burden to others | 50 (16.7;75) | 58.33 (25;75) | 0.1035 | 66.7 (25;83.3) | 0.0792 |
| - Emotional Health | 62.5 (41.7;83.3) | 70.8 (45.8;83.3) | 0.4374 | 75 (62.5;83.3) | 0.0133 |
| - Body image | 62.5 (35;80) | 70 (55;80) | 0.0737 | 70 (45;81.3) | 0.3042 |
| - Fatigue | 43.8 (25;68.8) | 50 (25;68.8) | 0.3019 | 56.3 (37.5;81.3) | 0.0127 |
| EQ-5D Index, Median (IQR) | 0.64 (0.48;0.74) | 0.64 (0.54;0.78) | 0.3985 | 0.71 (0.59;0.83) | 0.0087 |
| EQ-5D VAS, Median (IQR) | 51 (38;70) | 51 (40;73) | 0.2579 | 68 (51;71) | 0.0132 |
Severe CLASI-A: CLASI activity score ≥ 21; 28-SJC: Number of swollen joints in 28-joint count.
* Comparison between patients in severe disease activity (SDA) by SLE-DAS+BILAG-2004 versus patients classified in SDA only by SLE-DAS or BILAG-2004, using Chi-squared, Fishers’ or Mann-Whitney tests as appropriate.