Table 3

Difference in solid organ neoplasm-related deaths for patients with SLE and the general Spanish population by lineage

Neoplasm-related deaths n (%)
Non-SLESLEP valueOR (95% CI)*
Solid organ neoplasm127 080 (91.1)73 (80.2)0.0010.393 (0.234 to 0.660)
Malign solid organ neoplasm124 831 (89.5)72 (79.1)0.0030.432 (0.260 to 0.720)
 Digestive system415 778 (29.8)13 (14.3)0.0010.423 (0.240 to 0.747)
  Gastrointestinal tract24 573 (17.6)5 (5.5)0.0030.318 (0.129 to 0.784)
   Oesophagus2320 (1.7)1 (1.1)10.785 (0.109 to 5.669)
   Stomach6426 (4.6)3 (3.3)0.8010.764 (0.242 to 2.417)
   Small bowel459 (0.3)01
   Colorectal15 062 (10.8)1 (1.1)0.0010.110 (0.015 to 0.789)
   Others306 (0.2)01
  Hepato-biliary-pancreas17 005 (12.2)8 (8.8)0.4220.709 (0.342 to 1.470)
   HCC and others3815 (2.7)2 (2.2)10.906 (0.217 to 3.781)
   Pancreas8708 (6.2)3 (3.3)0.3810.491 (0.155 to 1.553)
   Cholangiocarcinoma4482 (3.2)3 (3.3)0.7691.109 (0.350 to 3.514)
 Lung25 886 (18.6)17 (18.7)11.204 (0.698 to 2.0760
 Breast3630 (2.6)2 (2.2)10.449 (0.109 to 1.847)
 Gynaecological4131 (3)8 (8.8)0.0063.039 (0.145 to 6.307)
  Vulva279 (0.2)2 (2.2)0.01514.767 (3.587 to 60.792)
  Vagina63 (0.1)01
  Cervical648 (0.5)3 (3.3)0.0093.809 (1.182 to 12.272)
  Uterus1263 (0.9)1 (1.1)0.4960.990 (0.137 to 7.168)
  Ovarian1747 (1.3)2 (2.2)0.3161.031 (0.251 to 4.236)
  Other131 (0.1)01
 Otorhinolaryngological4104 (2.9)5 (5.5)0.1972.183 (0.875 to 5.446)
 Endocrine1782 (1.3)00.634
  Thyroid329 (0.3)01
  Neuroendocrine1291 (0.9)01
 Skin1025 (0.7)1 (1.1)0.4891.665 (0.232 to 11.978)
  Melanoma532 (0.4)01
 Central nervous system4029 (2.9)2 (2.2)10.611 (0.150 to 2.497)
 Urological11 069 (7.9)5 (5.5)0.5581.125 (0.447 to 2.831)
  Prostate3289 (2.4)1 (1.1)0.7280.982 (0.132 to 7.325)
  Kidney2136 (1.5)2 (2.2)0.4071.580 (0.389 to 6.426)
  Bladder5147 (3.7)2 (2.2)0.7770.965 (0.235 to 3.970)
  Others497 (0.4)01
 Others4.212 (3)3 (3.3)0.7561.005 (0.318 to 3.179)
 Metastasis from unknown/unspecified origin23 385 (16.8)16 (17.6)0.7800.864 (0.501 to 1.488)
Benign solid organ neoplasm727 (0.5)00.596
Unknown behaviour solid organ neoplasm1327 (1)01
Carcinoma in situ186 (9.1)1 (1)0.124
  • Values in bold highlight statistically significant difference.

  • *After adjustment for age, sex, alcohol and tobacco consumption.

  • HCC, hepatocellular carcinoma.