Test set | Diagnostic criteria | LN definition | Sensitivity, % | Specificity, % | PPV, % | NPV, % | Accuracy, % |
UCSF | ≥1 ICD code | Strict | 56 | 94 | 83 | 81 | 81 |
Inclusive | 51 | 97 | 91 | 74 | 78 | ||
≥2 ICD codes, ≥30 days apart | Strict | 50 | 96 | 85 | 79 | 80 | |
Inclusive | 43 | 95 | 85 | 71 | 74 | ||
ZSFG (external set) | ≥1 ICD code | Strict | 73 | 92 | 85 | 83 | 84 |
Inclusive | 65 | 93 | 88 | 76 | 80 | ||
≥2 ICD codes, ≥30 days apart | Strict | 55 | 95 | 88 | 76 | 79 | |
Inclusive | 50 | 96 | 92 | 69 | 75 |
Performance of LN diagnosis codes for identifying prevalent cases of LN.
Inclusive, definite LN, potential LN or diagnostic uncertainty; NPV, negative predictive value; PPV, positive predictive value; Strict, definite LN only; UCSF, University of California San Francisco; ZSFG, Zuckerberg San Francisco General.