Elsevier

Cytokine

Volume 12, Issue 10, October 2000, Pages 1561-1565
Cytokine

Short Communication
SERUM LEVELS OF IFN-INDUCIBLE PROTEIN-10 RELATING TO THE ACTIVITY OF SYSTEMIC LUPUS ERYTHEMATOSUS

https://doi.org/10.1006/cyto.2000.0757Get rights and content

Abstract

IFN-inducible protein-10 (IP-10) is supposed to act as a specific chemoattractant for Th1cells. Since Th1cells and IFN-γ are shown to be important for developing systemic lupus erythematosus (SLE), we examined the relationship between serum IP-10 levels and the disease activity. Serum IP-10 levels were markedly increased in the SLE patients depending on the level of disease activity, whereas not in the patients with rheumatoid arthritis (RA). On the other hand, serum MCP-1 levels were increased to a similar extent both in RA and inactive SLE patients, and a little more elevated in active SLE patients. Serum IP-10 levels in SLE patients correlated positively and negatively with levels of anti-DNA antibody and complements, respectively, whereas MCP-1 levels correlated less or not at all. These results suggest that serum IP-10 levels could be a good indicator for the activity of SLE and that IP-10 could play an important immunological role in SLE.

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    Our findings were consistent with several previous studies. Some studies revealed that IL-6, IL-10, and IP-10 were highly expressed in SLE patients compared with healthy individuals, and IL-10 was associated with disease activity in SLE patients [19,33,34]. However, Metsariune et al. did not find significant differences in IL-6 concentrations between SLE patients and healthy controls [35].

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Correspondence to: Shosaku Narumi, Department of Molecular Preventive Medicine, School of Medicine, University of Tokyo, 7-3-1, Hongo, Bunkyo-ku, Tokyo 113, Japan. E-mail:[email protected]

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