Regular ArticlesQuantitative and Qualitative Analysis of the Balance Between Type 1 and Type 2 Cytokine-producing CD8−and CD8+T Cells in Systemic Lupus Erythematosus
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Cancer-associated immune-mediated syndromes: Pathogenic values and clinical implementation
2007, Biomedicine and PharmacotherapyCitation Excerpt :CD69+-marker was detected by means of “Fast-Immune” kit (BD, USA); CD34+-marker was detected by Bohbot method [39] using a “CEPRATE LC CD34” kit (CellPro, USA). Peripheral blood Th1- and Th2-cells ratio was assessed by evaluation of intracellular cytokines in CD4+-lymphocytes (IL-2 and IFN-γ for Th1-cells and IL-4 for Th2-cells) by means of flow cytometry [40–42]. Cytokines secretion was assessed by counting of circulating levels of serum IL-10; IFN-γ; TGF-β; and pivotal Th1 and Th2 cytokines, using ELISA kits (Innogenetics, Belgium; R&D Systems, UK; Biomar Diagnostics Systems, Germany; Promega, USA).
Cytokines in Systemic Lupus Erythematosus
2007, Systemic Lupus Erythematosus: A Companion to RheumatologyEffect of CD4+CD25+ regulatory T-cells on CD8 T-cell function in patients with autoimmune hepatitis
2005, Journal of AutoimmunityCitation Excerpt :CD4+CD25+ T-regs have also been reported to down-regulate the production of IFNγ by CD8 T-cells in a murine model and in humans [20,21]. In addition to an IFNγ producing subset, another CD8 T-cell subpopulation has been recently described that produces IL-4 [22], a cytokine with immune down-regulating properties [23,24]. To date no studies have investigated the ability of T-regs to regulate CD8 T-cell cytokine response in patients with autoimmune hepatitis.
Phenotypic and functional analysis of EBV-specific memory CD8 cells in SLE
2005, Cellular ImmunologyCitation Excerpt :Furthermore, peptide pool-specific IFN-γ-producing PBMC frequencies were similar in SLE and healthy control subjects, and comparable with the results for fresh PBMC published by Currier et al. [22]. Altogether, the results do not support a global virus-specific CD8 cell dysfunction in SLE subjects as previously described using other assay methodologies [4,56–58]. Though this data set is small and only two functional activities of CD8 cells were measured, it appears that a specific impairment in anti-EBV-BMLF-1-specific CD8 immunity is present in SLE.
Elevation of Metrnβ and Its Association with Disease Activity in Systemic Lupus Erythematosus
2023, International Journal of Molecular SciencesCD8<sup>+</sup> T Cell Phenotype and Function in Childhood and Adult-Onset Connective Tissue Disease
2022, International Journal of Molecular Sciences
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Correspondence to: Dr Mohammad Rasoul Amel-Kashipaz, Division of Immunology, A Floor West Block, Queen's Medical Centre, Nottingham NG7 2UH, United Kingdom. Fax: +44 (0) 115 970 9125. Email:[email protected]