Regular ArticleSelection of Recurrent V Genes and Somatic Mutations in Autoantibodies to DNA
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Cell- and nuclear-penetrating anti-dsDNA autoantibodies have multiple arginines in CDR3 of VH and increase cellular level of pERK and Bcl-2 in mesangial cells
2015, Molecular ImmunologyCitation Excerpt :In addition, we analyzed the sequences of the VH/VL of G2-6 and G5-8 and VH of H241. 2C10 IgG is one of the candidates for pathogenic anti-DNA Ab, as being supported by previous demonstration; pathogenicity of anti-DNA Abs correlates with the high affinity for dsDNA, high isoelectric point (pI), and the presence of higher than usual numbers of basic amino acids such as arginine and lysine in CDR sequences of V regions (Winfield et al., 1977; Radic and Seal, 1997; Dang and Harbeck, 1982; Gavalchin et al., 1985; Marion et al., 1992; Jang and Stollar, 2003). One sentence here has been deleted.
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