Abstract
Sjögren’s syndrome (S.S.) in the human patient population is an autoimmune inflammatory disease presenting clinical symptoms of xerophthalmia and xerostomia1. This condition predominantly affects women. Most diagnoses of S.S. is made in association with autoimmune connective tissue diseases such as rheumatoid arthritis or systemic lupus erythematosus.2 However, it can also be obseved as an isolated phenomenon, described as primary S.S.
This is a preview of subscription content, log in via an institution.
Buying options
Tax calculation will be finalised at checkout
Purchases are for personal use only
Learn about institutional subscriptionsPreview
Unable to display preview. Download preview PDF.
References
K.J. Bloch, W.W. Buchanan, M.J. Wohl, and J.J. Bunin, Sjögren’s syndrome: a clinical, pathological, and serological study of 62 cases, Medicine 44:187 (1965).
M.A. Alspaugh and K. Whaley, “Sjögren’s Syndrome: Textbook of Rheumatology,” E.D. Harris Jr., S. Ruddy and C.B. Sledge, eds., W.B. Saunder Co., Philadelphia (1981).
I. Schwartz, Lacrimal and salivary gland inflammation in the C3H/lpr autoimmune strain mouse: A potential mode for Sjögrens syndrome, Otolaryngol. Head Neck Surg. 106:394 (1992).
H.S. Kessler, A laboratory model for Sjögrens syndrome, Am. J. Pathol, 52:671 (1968).
R. Jonsson, A. Tarkowski, K. Bäckman, R. Holmdahl, and L. Klareskog, Sialadenitis in the MRL-1 mouse: morphological and immunohistochemical characterization of resident and infiltrating cells, Immunol. 60:611 (1987).
I. Sørensen, A.P. Ussing, J.U. Prause, J. Blom, S. Larsen and J.V. Spärck, Histological changes in exocrine glands of murine transplantation chimeras. I: The development of Sjögrens syndrome-like changes secondary to GVH induced lupus syndrome, Autoimmunity 11:261 (1992).
R.W. Hoffman, M.A. Alspaugh, K.S. Waggie, J.B. Durham and S.E. Walker, Sjögrens syndrome in MRL/l and MRL/n mice, Arthritis Rheum. 27:157 (1984).
A. Wolff, J. Scott, K. Woods and P.C. Fox, An investigation of parotid gland function and histopathology in autoimmune disease-prone mice of different age groups, J. Oral Pathol. Med. 20:486 (1991).
A.P. Ussing, J.W. Prause, I. Lørensen, S. Larsen and J.V. Spärck, Histological changes in exocrine glands of murine transplantation chimeras. II: Sjögren’s syndrome-like exocrinopathy in mice without lupus nephritis. A model of primary Sjögren’s syndrome, Autoimmunity 11:273 (1992).
G. Eisenbarth, Insulin dependent diabetes mellitus: a chronic autoimmune disease, N. Engl. J. Med. 314:1360 (1986).
L.M. Screebny, A. Yu, A. Green, and A. Valdini, Xerostomia in diabetes mellitus, Diabetes Care 15:900 (1992).
P.A. Gottlieb, A.A. Rossini and J.P. Mordes, Approaches to prevention and treatment of IDDM in animal models, Diabetes Care 11:29 (Suppl. 1) (1988).
H. Asamoto, M. Oishi, Y. Akagawa, and Y. Tochino, Histologic and immunologic changes in the thymus ad other organs in NOD mice, in: “Insulitis and Type 1 Diabetes,” T. Seiichiro, Y. Tochino, and K. Noraka, Eds., Academic Press, Tokyo (1986).
Y. Hu, Y. Nakagawa, K.R. Purushotham and M.G. Humphreys-Beher, Functional changes in salivary glands of autoimmue disease-prone NOD mice, Am. J. Physiol. 263:E607.
M.G. Humphreys-Beher, L. Brinkley, K.R. Purushotham, P.-L. Wang, Y. Nakagawa, D. Dusek and E.K.L. Chan, Characterization of antinuclear antibodies present in the serum from non-obese diabetic (NOD) mice, A. J. Physiol. submitted.
E.K.L. Chan and L.E.C. Andrade, Antinuclear antibodies in Sjögrens syndrome, in: “Rheumatic Disease Clinics of North America,” R.I. Fox, ed., W.B. Saunders Co., Philadelphia (1992).
Author information
Authors and Affiliations
Editor information
Editors and Affiliations
Rights and permissions
Copyright information
© 1994 Springer Science+Business Media New York
About this chapter
Cite this chapter
Humphreys-Beher, M.G., Hu, Y., Nakagawa, Y., Wang, PL., Purushotham, K.R. (1994). Utilization of the Non-Obese Diabetic (NOD) Mouse as an Animal Model for the Study of Secondary Sjögren’s Syndrome. In: Sullivan, D.A. (eds) Lacrimal Gland, Tear Film, and Dry Eye Syndromes. Advances in Experimental Medicine and Biology, vol 350. Springer, Boston, MA. https://doi.org/10.1007/978-1-4615-2417-5_105
Download citation
DOI: https://doi.org/10.1007/978-1-4615-2417-5_105
Publisher Name: Springer, Boston, MA
Print ISBN: 978-1-4613-6025-4
Online ISBN: 978-1-4615-2417-5
eBook Packages: Springer Book Archive