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The genetic basis of Ro and La antibody formation in systemic lupus erythematosus

Results of a multicenter study

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Summary

Antibodies against Ro and La, including recombinant La and recombinant 60 kD-Ro, were determined by counter immunoelectrophoresis and ELISA in over 300 central European systemic lupus erythematosus (SLE) patients. The presence of both Ro and La antibodies was strongly associated with the MHC haplotype B8-C4AQ0-DR3-DQ2, the association being stronges for DR3. After exclusion of all B8-DR3 positive patients only DR3 positive patients still showed an increased incidence of Ro and La antibodies, suggesting DR3 as the primary association factor. High titers of La antibody, but not of 60 kD-Ro antibody, were also significantly associated with the presence of DR3. Other DR and DQ antigens or heterozygous DQ combinations were not significantly associated with Ro and La antibodies.

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Authors and Affiliations

  1. Department of Medicine, University of Hannover, Germany

    R. Coldewey, R. Müller & H. Deicher

  2. Department of Immunology and Blood Bank, University of Hannover, Germany

    R. Müller & H. Deicher

  3. Department of Medicine, University of Erlangen, Germany

    F. Krapf

  4. Department of Immunology and Blood Bank, University of Erlangen, Germany

    F. Krapf

  5. Department of Medicine, University of Freiburg, Germany

    B. Lang

  6. Department of Immunology and Blood Bank, University of Freiburg, Germany

    B. Lang

  7. Department of Medicine, University of Düsseldorf, Germany

    H. J. Lakomek

  8. Department of Immunology and Blood Bank, University of Düsseldorf, Germany

    H. J. Lakomek

  9. Department of Medicine, Univerity of München, Germany

    D. Schendel

  10. Department of Immunology and Blood Bank, Univerity of München, Germany

    D. Schendel

  11. Private Institute of Immunology and Molecular Genetics, Karlsruhe, Germany

    H. Ehrfeld & H. P. Seelig

  12. Abteilung Immunologie und Transfusionsmedizin, Medizinische Hochschule Hannover, Konstanty-Gutschow-Strasse 8, W-3000, Hannover 61, Germany

    K. Hartung

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E. Albert, M. Baur, A. Corvetta, J. Frey, J. R. Kalden, G. G. de Lange, H. H. Peter, K. Pirner, R. Röther, P. Schneider, S. Seuchter, P. Späth, C. Specker, W. Stangel, S. Stannat-Kießling

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Hartung, K., Coldewey, R., Ehrfeld, H. et al. The genetic basis of Ro and La antibody formation in systemic lupus erythematosus. Rheumatol Int 11, 243–249 (1992). https://doi.org/10.1007/BF00301501

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  • DOI: https://doi.org/10.1007/BF00301501

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