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Anti-Ro antibody and cutaneous vasculitis in systemic lupus erythematosus

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Abstract

Systemic lupus erythematosus (SLE) is a complex systemic autoimmune disease with various clinical and serological manifestations. Previous studies have shown the association of SLE and anti-Ro antibody with a series of clinical manifestations. We investigated this association in Brazilian patients with SLE. Five hundred and nine consecutive patients who fulfilled the revised American College of Rheumatology criteria for the SLE were enrolled in the study from June to December 2007. All patients were from our Service of Rheumatology, School of Medicine, University of São Paulo, Brazil. Frequencies of a series of laboratorial and clinical manifestations were calculated. Anti-Ro antibody was associated to anti-La antibody, female, and cutaneous vasculitis. In multivariate analysis, patients with anti-Ro antibody has 1.63 (95% CI 1.07–2.50) more risk to develop cutaneous vasculitis than patients without this antibody. Our data have demonstrated that anti-Ro antibody is an independent useful serologic marker for cutaneous vasculitis.

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References

  1. Sibilia J (1998) Ro (SS-A) and anti-Ro (SS-A): an update. Rev Rhum Engl Ed 65:45–57

    PubMed  CAS  Google Scholar 

  2. Harley JB, Scofield RH, Reichlin M (1992) Anti-Ro in Sjögren’s syndrome and systemic lupus erythematosus. Rheum Dis Clin North Am 18:337–358

    PubMed  CAS  Google Scholar 

  3. Penner E, Reichlin M (1982) Primary biliary cirrhosis associated with Sjögren’s syndrome: evidence for circulating and tissue-deposited Ro/anti-Ro immune complexes. Arthritis Rheum 25:1250–1253

    Article  PubMed  CAS  Google Scholar 

  4. Cavazzana I, Franceschini F, Quinzanini M, Manera C, Del Papa N, Maglione W, Comina D, Radice A, Sinico RA, Cattaneo R (2006) Anti-Ro/SSA antibodies in rheumatoid arthritis: clinical and immunologic associations. Clin Exp Rheumatol 24:59–64

    PubMed  CAS  Google Scholar 

  5. Wolin SL, Reinisch KM (2006) The Ro 60 kDa autoantigen comes into focus: interpreting epitope mapping experiments or structure. Autoimmun Rev 5:367–372

    Article  PubMed  CAS  Google Scholar 

  6. Provost TT, Levin LS, Watson RM, Mayo M, Ratrie H 3rd (1991) Detection of anti Ro(SSA) antibodies by gel double diffusion and a sandwich ELISA in systemic and subacute cutaneous lupus erythematosus and Sjogren’s syndrome. J Autoimmun 4:87–96

    Article  PubMed  CAS  Google Scholar 

  7. Clark G, Reichlin M, Tomasi TB (1969) Characterization of a soluble cytoplasmic antigen reactive with sera from patients with systemic lupus erythematosus. J Immunol 102:117–122

    PubMed  CAS  Google Scholar 

  8. Maddison PJ, Mogavero M, Provost TT, Reichlin M (1976) The clinical significance of autoantibodies to a soluble cytoplasmic antigen in systemic lupus erythematosus and other connective tissue diseases. J Rheumatol 6:189–195

    Google Scholar 

  9. Synkowski DR, Reichlin M, Provost TT (1982) Serum autoantibodies in systemic lupus erythematosus and correlation with cutaneous features. J Rheumatol 9:380–385

    PubMed  CAS  Google Scholar 

  10. Hochberg MC, Boyd RE, Aheran JM, Arnett FC, Bias WB, Provost TT, Stevens MB (1985) Systemic lupus erythematosus: a review of clinico-laboratory features and immunogenetic markerjs in 150 patients with emphasis on demographic subsets. Medicine 64:285–295

    Article  PubMed  CAS  Google Scholar 

  11. Mond CB, Peterson MG, Rothfield NF (1989) Correlation of anti-Ro antibody with photosensitivity rash in systemic lupus erythematosus patients. Arthritis Rheum 32:202–204

    Article  PubMed  CAS  Google Scholar 

  12. Sutej PG, Gear AJ, Morrison RC, Tikly M, de Beer M, Dos Santos L, Sher R (1989) Photosensitivity and anti-Ro (SS-A) antibodies in black patients with systemic lupus erythematosus (SLE). Br J Rheumatol 28:321–324

    Article  PubMed  CAS  Google Scholar 

  13. Kurien BT, Newland J, Paczkowski C, Moore KL, Scofield RH (2000) Association of neutropenia in systemic lupus erythematosus (SLE) with anti-Ro and binding of an immunologically cross-reactive neutrophil membrane antigen. Clin Exp Immunol 120:209–217

    Article  PubMed  CAS  Google Scholar 

  14. Vilá LM, Molina MJ, Mayor AM, Peredo RA, Santaella ML, Vilá S (2006) Clinical and prognostic value of autoantibodies in Puerto Ricans with systemic lupus erythematosus. Lupus 15:892–898

    Article  PubMed  Google Scholar 

  15. Costedoat-Chalumeau N, Georgin-Lavialle S, Amoura Z, Piette JC (2005) Anti-SSA/Ro and anti-SSB/La antibody-mediated congenital heart block. Lupus 14:660–664

    Article  PubMed  CAS  Google Scholar 

  16. Clancy RM, Neufing PJ, Zheng P, O’Mahony M, Nimmerjahn F, Gordon TP, Buyon JP (2006) Impaired clearance of apoptotic cardiocytes is linked to anti-SSA/Ro and –SSB/La antibodies in the pathogenesis of congenital heart block. J Clin Invest 116:2413–2422

    PubMed  CAS  Google Scholar 

  17. La zzerini PE, Capecchi PL, Guideri F, Acampa M, Galeazzi M, Laghi-Pasini F (2006) Connective tissue diseases and cardiac rhythm disorders: an overview. Autoimmun Rev 5:306–313

    Article  PubMed  Google Scholar 

  18. Shahin AA, Shahin HA, Hamid MA, Amin MA (2004) Cardiac involvement in patients with systemic lupus erythematosus and correlation of valvular lesions with anti-Ro/SS-A and anti-La/SS-B antibody levels. Mod Rheumatol 14:117–122

    Article  PubMed  Google Scholar 

  19. Oshiro AC, Derbes SJ, Stopa AR, Gedalia A (1997) Anti-Ro/SS-A and anti-La/SS-B antibodies associated with cardiac involvement in childhood systemic lupus erythematosus. Ann Rheum Dis 56:i272–i274

    Article  Google Scholar 

  20. Alexander EL, Arnett FC, Provost TT, Stevens MB (1983) Sjögren’s syndrome: association of anti-Ro (SS-A) antibodies with vasculitis, hematologic abnormalities, and serologic hyperreactivity. Ann Intern Med 98:155–159

    PubMed  CAS  Google Scholar 

  21. Moutsopoulos HM, Zerva LV (1990) Anti-Ro (SSA)/La (SSB) antibodies and Sjögren’s syndrome. Clin Rheumatol 9(1 Suppl 1):123–130

    Article  PubMed  CAS  Google Scholar 

  22. Alexander EL, Provost TT (1983) Cutaneous manifestations of primary Sjögren’s syndrome: a refletion of vasculitis and association with anti-Ro (SSA) antibodies. J Invest Dermatol 80:386–391

    Article  PubMed  CAS  Google Scholar 

  23. Alexander EL, Provost TT (1987) Sjögren’s syndrome. Association of cutaneous vasculitis with central nervous system disease. Arch Dermatol 123:801–810

    Article  PubMed  CAS  Google Scholar 

  24. Alexander EL, Hirsch TJ, Arnett FC, Provost TT, Stevens MB (1982) Ro (SSA) and La (SSB) antibodies in the clinical spectrum of Sjögren’s syndrome. J Rheumatol 9:239–246

    PubMed  CAS  Google Scholar 

  25. Cho CS, Park SH, Min JK, Lee SH, Kim HY (1997) Clinical significances of antibodies to Ro/SS-A autoantigens and its subtypes in primary Sjögren’s syndrome. Korean J Intern Med 12:176–181

    PubMed  CAS  Google Scholar 

  26. Boire G, Ménard HA (1988) Clinical significance of anti-Ro (SSA) antibody in rheumatoid arthritis. J Rheumatol 15:391–394

    PubMed  CAS  Google Scholar 

  27. Magro CM, Crowson AN (2003) The spectrum of cutaneous lesions in rheumatoid arthritis: a clinical and pathological study of 43 patients. J Cutan Pathol 30:1–10

    Article  PubMed  CAS  Google Scholar 

  28. Hochberg MC (1997) Updating the American College of Rheumatology revised criteria for the classification of systemic lupus erythematosus [letter]. Arthritis Rheum 40:1725

    Article  PubMed  CAS  Google Scholar 

  29. McCauliffe DP (1997) Cutaneous diseases in adults associated with Anti-Ro/SS-A autoantibody production. Lupus 6:158–166

    Article  PubMed  CAS  Google Scholar 

  30. Dubois EL, Tuffanelli DL (1964) Clinical manifestations of systemic lupus erythematosus. Computer analysis of 520 cases. JAMA 190:104–111

    PubMed  CAS  Google Scholar 

  31. Harvey AM, Shulman LE, Tumulty PA, Conley CL, Schoenrich EH (1954) Systemic lupus erythematosus: review of the literature and clinical analysis of 138 cases. Medicine (Baltimore) 33:291–437

    Article  CAS  Google Scholar 

  32. Yell JA, Mbuagbaw J, Burge SM (1996) Cutaneous manifestations of systemic lupus erythematosus. Br J Dermatol 135:355–362

    Article  PubMed  CAS  Google Scholar 

  33. Grigor R, Edmonds J, Lewkonia R, Bresnihan B, Hughes GR (1978) Systemic lupus erythematosus. A prospective analysis. Ann Rheum Dis 37:121–128

    Article  PubMed  CAS  Google Scholar 

  34. Bouaziz JD, Barete S, Le Pelletier F, Amoura Z, Piette JC, Francès C (2007) Cutaneous lesions of the digits in systemic lupus erythematosus: 50 cases. Lupus 16:163–167

    PubMed  CAS  Google Scholar 

  35. Watson R (1989) Cutaneous lesions in systemic lupus erythematosus. Med Clin North Am 73:1091–1111

    PubMed  CAS  Google Scholar 

  36. Drenkard C, Villa AR, Reyes E, Abello M, Alarcón-Segovia D (1997) Vasculitis in systemic lupus erythematosus. Lupus 6:235–242

    Article  PubMed  CAS  Google Scholar 

  37. Provost TT, Watson R, Simmons-O’Brien E (1996) Anti-Ro (SS-A) antibody positive Sjögren’s/lupus erythematosus overlap syndrome. Lupus 6:105–111

    Article  Google Scholar 

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Authors and Affiliations

  1. Division of Rheumatology, School of Medicine, University of São Paulo, Av. Dr. Arnaldo, 455, Sala 3133, CEP 01246-903, São Paulo, Brazil

    Márcio Veronesi Fukuda, Simone Chinwa Lo, Cláudia Salvini de Almeida & Samuel Katsuyuki Shinjo

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  1. Márcio Veronesi Fukuda
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  2. Simone Chinwa Lo
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  3. Cláudia Salvini de Almeida
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  4. Samuel Katsuyuki Shinjo
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Correspondence to Samuel Katsuyuki Shinjo.

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Fukuda, M.V., Lo, S.C., de Almeida, C.S. et al. Anti-Ro antibody and cutaneous vasculitis in systemic lupus erythematosus. Clin Rheumatol 28, 301–304 (2009). https://doi.org/10.1007/s10067-008-1043-5

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  • DOI: https://doi.org/10.1007/s10067-008-1043-5

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