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Analysis of clinical manifestations and pathology of lupus nephritis: a retrospective review of 82 cases

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Abstract

Lupus nephritis (LN) is a common secondary glomerular disease with diverse clinical manifestations and pathology. We retrospectively analyzed the clinical manifestations and pathology of 82 hospitalized LN patients (73 females and nine males) during February 2004 to February 2009. The mean age at disease onset of male patients was much younger than female patients (27.6 ± 6.8 vs. 35.5 ± 13.9). The kidney biopsy showed that more than 50% was IV-type LN. The II- and III-type LN were also common; their clinical manifestations were common in nephritic syndrome and (or) asymptomatic urinary abnormalities, whereas IV- and V-type LN usually presented nephrotic syndrome. Simultaneously, we investigated that the highest incidence rates of anemia and chronic renal failure were observed in IV- and IV + V-type LN. What was more, we found that serum creatinine level was higher; the interstitial involvement was more severe with renal biopsy. The serum creatinine level and renal interstitial lesions were positively correlated. Our study showed that the different pathologic phenotypes of LN were correlated with the specific clinical manifestations. However, the conclusion should be confirmed by large-scale prospective research.

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Disclosures

All authors of this manuscript affirm that neither the manuscript nor any significant part of it is under consideration for publication elsewhere, or has appeared elsewhere in a manner that could be as prior or duplicate publication of the same, or very similar, work. In addition, none of the authors received any significant primary financial arrangements with commercial companies to produce or sell products or with competitors of such companies.

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Authors and Affiliations

  1. Department of Nephrology, The Second Hospital, Jilin University, Changchun, 130041, China

    Qiaoyan Guo, Xuehong Lu, Lining Miao, Man Wu & Ping Luo

  2. Department of Nephrology, The First Hospital, Zhengzhou University, Zhengzhou, 450052, China

    Shan Lu

  3. The Second Hospital, Norman Bethune Medical College, Jilin University, Changchun, 130041, China

    Ping Luo

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  1. Qiaoyan Guo
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  2. Xuehong Lu
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  3. Lining Miao
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  4. Man Wu
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  5. Shan Lu
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Correspondence to Ping Luo.

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Qiaoyan Guo and Xuehong Lu contributed equally to this work.

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Guo, Q., Lu, X., Miao, L. et al. Analysis of clinical manifestations and pathology of lupus nephritis: a retrospective review of 82 cases. Clin Rheumatol 29, 1175–1180 (2010). https://doi.org/10.1007/s10067-010-1517-0

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  • DOI: https://doi.org/10.1007/s10067-010-1517-0

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