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Correlation between levels of TNF-α and IL-6 and hematological involvement in SLE Egyptian Patients with lupus nephritis

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Abstract

Background

Systemic lupus Erythematosus (SLE) is a rheumatic autoimmune disease characterized by multisystem organ involvement and by high titers of auto antibodies against several nuclear and cytoplasmic antigens. Numerous abnormalities of the cytokine network have been described in patients suffering from SLE. However the role of cytokines in different organ involvement is not yet well defined.

Objective

To determine if levels of Interlukin-6 (IL-6) and Tumor necrosis factor (TNF-α) correlate with SLE disease activity in Egyptian SLE patients and more specifically with hematological involvement.

Methods

Levels of TNF-α and IL-6 in serum samples from sixty individuals (40 with Systemic lupus Erythmatosus and 20 healthy controls) were determined and renal biopsies were obtained from SLE patients.

Results

Levels of TNF-α and IL-6 were higher in SLE patients with active compared with inactive hematological disease. Further analysis showed that this association was dependent on inverse correlation (P=0.017, r=−0.49) for IL-6 and (P=0.76, r=−.243) for TNF-α. The mean level of TNF-α and Il-6 was (766.95±357.82 pg/ml) and (135.4±54.23 pg/ml) respectively for patients with active disease while it was (314.01±100.87 pg/ml) and (47.33±18.61 pg/ml) for those with inactive disease and (172.7±39.19 pg/ml) and (21.15±10.99 pg/ml) for the healthy control group respectively. The difference was statistically significant (P=0.002). We found significant positive correlations between TNF-α and IL-6 and the SLE Disease Activity Index (SLEDAI) score. (r=+0.743 and +0.772 respectively).

Conclusion

Raised level of Il-6 and TNF-α may influence the development of anemia in Egyptian patients with Lupus Nephritis.

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Authors and Affiliations

  1. Nephrology Department, Mansoura Urology and Nephrology Center, Mansoura University, Mansoura, Egypt

    Alaa Sabry, Hussein A. Sheashaa & Khaled Mahmoud

  2. Rheumatology and Rehabilitation Unit, Mansoura University, Mansoura, Egypt

    Sherief Refat Elbasyouni

  3. Mansoura Urology and Nephrology Center, Mansoura University, Mansoura, Egypt

    Amr A. Alhusseini

  4. Internal Medicine Department, Mansoura University, Mansoura, Egypt

    Shahir Kamal George & Ehab Abdel Kaleek

  5. Internal Medicine Department, Menoufya University, Menoufya, Egypt

    Hamdy abo-Zena

  6. Biochemistry Department, Mansoura Urology and Nephrology Center, Mansoura University, Mansoura, Egypt

    Abdalla M. Kalil

  7. Radiology Unit, Mansoura Urology and Nephrology Center, Mansoura University, Mansoura, Egypt

    Tareek Mohsen

  8. Pathology Unit, Mansoura Urology and Nephrology Center, Mansoura University, Mansoura, Egypt

    Mona Abdel Rahim

  9. Medical Biochemistry Department, Mansoura faculty of Medicine, Mansoura, Egypt

    Ayman Z. El-samanody

Authors
  1. Alaa Sabry
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  2. Sherief Refat Elbasyouni
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  3. Hussein A. Sheashaa
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Correspondence to Alaa Sabry.

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Sabry, A., Elbasyouni, S.R., Sheashaa, H.A. et al. Correlation between levels of TNF-α and IL-6 and hematological involvement in SLE Egyptian Patients with lupus nephritis. Int Urol Nephrol 38, 731–737 (2006). https://doi.org/10.1007/s11255-006-0047-9

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  • DOI: https://doi.org/10.1007/s11255-006-0047-9

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