Abstract
Systemic lupus erythematosus (SLE) is a chronic autoimmune disease that has major implications for health-related quality of life (HRQoL). Improvements in the monitoring and management of SLE improves survival; however, improvement of HRQoL remains of paramount importance among these patients. Measurement of HRQoL has been recommended in clinical practice and research including drug development and testing in clinical trials. Both generic and disease specific instruments have been developed to ascertain HRQoL. In an increasingly global collaborative environment, the importance of assessing HRQoL across nations, acknowledgment of their confounders, and limitations of used instruments are critical. Here, we review selected major developments in the past 5 years highlighting: the importance of measuring HRQoL in SLE patients, the benefits and limitations of instruments that exist, and their application in research settings.
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Conflict of Interest
Anisha B. Dua has served on a national advisory board for Amgen.
Zahi Touma has received honoraria from and is a consultant for GlaxoSmithKline and Janssen Research and Development, and has received royalties from www.sledai-2k.com and www.s2k-ri.50.com.
Meenakshi Jolly holds the copyrights to LupusPRO and LIT, has served as a consultant for GlaxoSmithKline, has received grant support from GlaxoSmithKline/The Binding Site, has received honoraria from GlaxoSmithKline, has received royalties from GlaxoSmithKline and MedImmune, has received payment for development of educational presentations (including service on speakers bureaus) from GlaxoSmithKline, and has had travel/accommodations expenses covered/reimbursed by GlaxoSmithKline.
Sergio Toloza declares that he has no conflict of interest.
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Dua, A.B., Touma, Z., Toloza, S. et al. Top 10 Recent Developments in Health-Related Quality of Life in Patients with Systemic Lupus Erythematosus. Curr Rheumatol Rep 15, 380 (2013). https://doi.org/10.1007/s11926-013-0380-9
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DOI: https://doi.org/10.1007/s11926-013-0380-9