Cerebrospinal fluid antibodies to neuronal cells: Association with neuropsychiatric manifestations of systemic lupus erythematosus☆
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Cited by (209)
Seizures in systemic lupus erythematosus: A scoping review
2021, SeizureCitation Excerpt :Gonzalez-Duarte and colleagues found mild pleocytosis or elevated proteins only in 12.5 % of patients [11]. Bluestein and colleagues also conducted a case-control study where NPSLE manifestations were in association to IgG anti-neuronal antibodies in the CSF [43]. There is no consensus in the antiepileptic treatment for SLE patients, individual decisions are made depending on clinical presentation (partial seizure, generalized tonic-clonic crisis or status epilepticus).
Lupus and the nervous system: Clinical aspects, psychopathology, and imaging
2018, Dubois' Lupus Erythematosus and Related SyndromesThe diagnosis and clinical management of the neuropsychiatric manifestations of lupus
2016, Journal of AutoimmunityAutoimmunity, neuroinflammation, pathogen load: A decisive crosstalk in neuropsychiatric SLE
2016, Journal of AutoimmunityCitation Excerpt :Both in murine models of lupus [25–28] and in patients [29,30], diffuse manifestations were found to result rather from inflammatory processes and toxicity mediated by Abs binding neuronal cell surface receptors, such as neuronal surface P antigen (NSPA) and N-methyl-d-aspartate receptor (NMDAR). The occurrence of autoAbs and proinflammatory cytokines in the cerebrospinal fluid (CSF), a liquid secreted within the choroid plexus and diffusing into the cerebroventricular compartments, could either result from leakages in the BBB (passive transfer) or from intrathecal production [31]. Breach of the BBB is critical for the access of Abs directed against NMDAR subunit 2 (anti-NR2, also known as anti-GluN2) to brain neurons [26,32,33].
Antibodies associated with neuropsychiatric lupus: Pathophysiological role, prevalence and diagnostic usefulness
2019, Revista Colombiana de Reumatologia
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This study was supported in part by Research Grant 79-00073 from the State of California, Department of Health Services, and U.S. Public Health Service Grants AI-10931 and AM-07062 from the National Institutes of Health.
- 1
From the Departments of Medicine, University of California, San Diego, San Diego, California.
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Present address: Rheumatology Division, Hospital of Scripps Clinic, 10666 N. Torrey Pines Rd., La Jolla, CA 92037.
- 2
From the Arthritis Branch, NIAMDD, National Institutes of Health, Bethesda, Maryland.