Original contributionPresence of tumor necrosis factor alpha and interleukin-6 in renal mesangial cells of lupus nephritis patients☆
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IL-6 and its role in IgA nephropathy development
2022, Cytokine and Growth Factor ReviewsCitation Excerpt :The main features of autoimmunity in SLE are B cell hyperactivity and production of IL-6, spontaneous lymphocyte proliferation, and the production of pathogenic antibodies recognizing self-antigens. In patients with lupus nephritis, the urinary levels of IL-6 also correlate with disease activity and the expression of IL-6 has been reported within the kidney tissue particularly in renal mesangial cells [76,77]. Engagement of the B-cell receptor (BCR) with autoantigen together with B cell overexpressed IL-6 down-regulates the level of B cell activation inhibitor - membrane CD5, promoting the activation and expansion of autoreactive B cells in SLE patients [78].
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This work was supported by grant MT-9702 from the Medical Research Council of Canada.