Elsevier

Dermatologic Clinics

Volume 19, Issue 4, 1 October 2001, Pages 711-726
Dermatologic Clinics

HAIR AND SYSTEMATIC DISEASE

https://doi.org/10.1016/S0733-8635(05)70310-7Get rights and content

Section snippets

Telogen Effluvium

The biologic clock that determines the end of the anagen phase and the beginning of the catagen/telogen phase is poorly understood. The human hair can only grow for a few months to years before it becomes a telogen hair and is shed. Entry of the hair follicle into the telogen phase is analogous to scheduled preventive maintenance on a machine. Hair shaft production is temporarily halted, and the follicle is retooled to begin a new growth cycle. Scalp hair grows longer than hair on other parts

Hypertrichosis

Hypertrichosis is defined as an excessive growth of non–androgen-dependent hair. It may be localized or generalized, congenital or acquired. A textbook of dermatologic syndromes22 lists 24 syndromes, most congenital, that have hypertrichosis as a feature. Large congenital melanocytic nevi may be hypertrichotic and place the patient at increased risk for developing a malignant melanoma. Hypertrichosis has been reported in association with multiple sclerosis and schizophrenia, 12 1 to 4 months

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      Our results showed a similar telogen count of 10.3% and a decreased (yet normal) terminal-to-vellus ratio of 4:1. In fact, chronic diffuse telogen effluvium is the most common form of hair loss in systemic disease, and both systemic lupus erythematosus and DM are documented causes for that.17 These conditions are associated with catabolic effects and a high level of proinflammatory cytokines during flare, which negatively affect the hair growth cycle.18

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    Address reprint requests to Leonard C. Sperling, MD Department of Dermatology Uniformed Services University 4301 Jones Bridge Rd. Bethesda, MD 20814 [email protected]

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