Preventive cardiologyRelation of Framingham Risk Score to Subclinical Atherosclerosis Evaluated Across Three Arterial Sites
Section snippets
Methods
The B-Vitamin Atherosclerosis Intervention Trial is a randomized, double-blind, placebo-controlled, clinical trial designed to test whether B-vitamin supplementation will reduce the progression of early carotid artery atherosclerosis in subjects with elevated fasting homocysteine, but without clinically evident cardiovascular disease. Briefly, potential subjects were prescreened by telephone and met initial screening eligibility if they were at least 40 years of age, postmenopausal (for women),
Results
Baseline data on all 3 atherosclerosis measures were available on 498 of 506 randomized subjects. Table 1 summarizes the demographics and other cardiovascular risk factors of these subjects. The mean ± SD age of the participants was 61 ± 10 years ranging from 40 to 88 years, and 61% were men. The majority of the participants (66%) were non-Hispanic White, 14% were Black, 11% Hispanic, and 9% were Asian; 37% of the subjects had smoked regularly in their lifetime. Overall, the study participants
Discussion
Our data indicate that the CAC, AC, and CIMT are independently associated with the Framingham 10-year CHD risk estimate. We also report that the 10-year FRS increases steadily with increasing number of prevalent atherosclerosis sites in asymptomatic patients.
The FRS is a useful tool for identifying subjects at relatively higher risk of CHD to implement primary prevention interventions. FRS has been shown to be significantly associated with CAC and CIMT in asymptomatic young adults.10, 11
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This work is supported by National Institutes of Health grant R01-AG17160, Bethesda, Maryland.