Autoantibody explosion in systemic lupus erythematosus: More than 100 different antibodies found in SLE patients
Section snippets
Methods
The English-language medical literature was searched for original articles describing autoantibodies in SLE. Using Medline, the search words used were “autoantibody” and “systemic lupus erythematosus” and the years searched were 1960 to 2001. The aim was to describe the various autoantibodies with respect to their target, the properties of the autoantigens targeted by these autoantibodies, and the prevalence of each of the autoantibodies in SLE, to determine if their presence or titers
Results
The literature search disclosed 116 different autoantibodies reported in SLE. Table 1, Table 2, Table 3, Table 4, Table 5, Table 6, Table 7, Table 8, Table 9, Table 10 (1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22, 23, 24, 25, 26, 27, 28, 29, 30, 31, 32, 33, 34, 35, 36, 37, 38, 39, 40, 41, 42, 43, 44, 45, 46, 47, 48, 49, 50, 51, 52, 53, 54, 55, 56, 57, 58, 59, 60, 61, 62, 63, 64, 65, 66, 67, 68, 69, 70, 71, 72, 73, 74, 75, 76, 77, 78, 79, 80, 81, 82, 83, 84, 85,
Discussion
In this article we summarized the diversity of autoantibodies in SLE. It is obvious that some autoantibodies are directed to nuclear and cytoplasmic macromolecules and to cell membranes, while others react with lipid components or attach to the cardiac conduction system. The antibodies differ in their binding characteristics and in their prevalence. Some are frequent such as anti-dsDNA, which nearly always appears in one stage or another of the disease (13, 14), while others have been described
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Cited by (0)
Y. Sherer and A. Gorstein contributed equally to this work.