Systemic lupus erythematosusDifferences in Autoantibody Profiles and Disease Activity and Damage Scores Between Childhood- and Adult-Onset Systemic Lupus Erythematosus: A Meta-Analysis
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Identification of Studies
A similar search strategy and methods have been described in a companion meta-analysis of clinical manifestations between cSLE and aSLE (3). A comprehensive literature search of the MEDLINE/PubMed, EMBASE, CINAHL, and SCOPUS databases was conducted (each from database inception to January 2011) using the following search terms: Systemic lupus erythematosus and Age factors/or Onset age/or Age of onset/or Age differences and Adult and Child. In addition, key references were hand searched to
Search Results
The literature search identified 484 articles, which were screened for eligibility (Fig. 1): 221 were repeated citations, 16 were not written in English, 43 were published before 1982, and 151 were deemed irrelevant based on a review of the title/abstract. The remaining 53 articles underwent a full text review, and an additional 37 articles were excluded: 25 had no comparative data on cSLE and aSLE, 9 had comparative data, but not on a variable of interest, 2 focused on a specialized subset of
Discussion
The results of this meta-analysis suggest that there are some differences in the autoantibody profiles, laboratory test results, and activity scores between cSLE and aSLE. As was expected, the majority of cSLE and aSLE patients had a positive ANA test, and there was no difference in the prevalence of a positive test between the 2 age groups. Other autoantibodies that showed no predilection for either age group included anti-Smith, anti-RNP, anti-U1RNP, anti-Ro, and anti-La. These findings are
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Cited by (41)
Neuropsychiatric manifestations in childhood-onset systemic lupus erythematosus
2022, The Lancet Child and Adolescent HealthCitation Excerpt :The improvement of survival in childhood-onset SLE is primarily a consequence of earlier diagnosis, better immunosuppressive treatment, and improved supportive care.96 However, a prolonged disease duration is associated with cumulative accrual damage, premature atherosclerosis, and neuropsychiatric manifestations, especially cerebrovascular disease and cognitive impairment.101–103 Children with SLE has been reported to have lower reading and mathematics achievement test scores than healthy peers and scores were associated with disease activity, cognitive impairment, and treatment intensity.104
Lupus in children
2020, Systemic Lupus Erythematosus: Basic, Applied and Clinical AspectsChildhood-Onset Systemic Lupus Erythematosus: A Review and Update
2018, Journal of PediatricsCitation Excerpt :Anti–double-stranded DNA positivity is very specific for SLE and present in up to 75% of patients with cSLE.42,64 These antibodies occur especially in the setting of active inflammation from cSLE, including lupus nephritis.67,68 Antibodies against extractable nuclear antigens, that is, anti-Smith, anti-ribonucleoprotein, anti-Ro (also called SS-A), and anti-La (also called SS-B) are other autoantibodies often encountered in cSLE.69,70
Juvenile lupus: Different clinical and serological presentations compared to adult lupus in Egypt
2018, Egyptian RheumatologistCitation Excerpt :However, other studies reported that oral ulcers are more common in children than adult SLE patients [16,22] and others found no differences regarding skin symptoms [3,25]. Based on the literature, frequency of serological abnormalities shows no significant difference between juvenile and adult forms [26,27]. In the current study, the ANAs were detected with similar frequency in both groups while the anti-DNA antibodies were more frequently detected among children.
Initial digital vasculitis in a large multicenter cohort of childhood‐onset systemic lupus erythematosus
2017, Revista Brasileira de ReumatologiaJuvenile-onset systemic lupus erythematosus (jSLE) – Pathophysiological concepts and treatment options
2017, Best Practice and Research: Clinical RheumatologyCitation Excerpt :Patients with disease onset before 5 years of age are very uncommon and may be referred to as early-onset SLE (eoSLE) [9,10]. Of note, jSLE, particularly eoSLE cases, is characterised by more severe clinical phenotypes, a high prevalence of pre-existing organ damage at diagnoses, more complications and less favourable outcomes compared to adult-onset SLE (aSLE) [7–13] (Table 1). The observations that gender distribution varies between age groups and that more severe phenotypes occur in patients with jSLE, particularly those with eoSLE, suggest that genetic causes or risk alleles may play a more pronounced role in jSLE.
- 1
Canadian Rheumatology Association (CRA) Roche Research Summer Studentship Award.
- 2
Amgen Summer Studentship Award.