Elsevier

Kidney International

Volume 82, Issue 8, 2 October 2012, Pages 840-856
Kidney International

Review
The KDIGO practice guideline on glomerulonephritis: reading between the (guide)lines—application to the individual patient

https://doi.org/10.1038/ki.2012.280Get rights and content
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The KDIGO guideline for glomerulonephritis is designed to assist health-care providers in treating patients with glomerular diseases. A guideline is not a set of rules but is intended to allow the practitioner to make an informed decision based on the available evidence. Due to its general nature and the variability of strength of the available studies, it is often difficult to directly apply a guideline to the care of an individual patient. This commonly relates to the limited generalizability of the evidence, i.e., does not cover every clinical scenario. To underscore this point, we have introduced within the context of the glomerulonephritis guideline cases with specific features to illustrate the constant need for clinical judgment. These vignettes are intended to demonstrate how the best treatment plans should be individualized and take into account patient preference and clinical acumen, as well as the best available evidence.

Keywords

evidence-based guideline
glomerulonephritis
nephrotic syndrome
randomized controlled trials
vasculitis

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Summary of Recommendation Statement is provided in the Appendix.

J.R.: Genentech advisory board. D.C.C. declares no competing interests.