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Phase II and phase III failures: 2013–2015

Nature Reviews Drug Discovery volume 15, pages 817–818 (2016)Cite this article

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During this time period, there were 218 reported failures between phase II (including phase I/II) and submission (each drug indication combination is considered as a separate record and both new active substances and new indications of marketed drugs are included in the analysis). Of these failures, 174 had stated the reason for the failure and these were used in the subsequent analysis.

Reasons for failure

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Figure 1: Reasons for clinical trial failures 2013–2015.
Figure 2: Recent trends in clinical trial failures.

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  1. Richard K. Harrison is the Chief Scientific Officer at Clarivate Analytics, 1500 Spring Garden Street, Philadelphia, Pennsylvania 19103, USA.,

    Richard K. Harrison

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  1. Richard K. Harrison
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Correspondence to Richard K. Harrison.

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The author declares no competing financial interests.

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Harrison, R. Phase II and phase III failures: 2013–2015. Nat Rev Drug Discov 15, 817–818 (2016). https://doi.org/10.1038/nrd.2016.184

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