Obesity therapy: altering the energy intake-and-expenditure balance sheet

Nat Rev Drug Discov. 2002 Apr;1(4):276-86. doi: 10.1038/nrd770.

Abstract

Obesity is associated with numerous health complications, which range from non-fatal debilitating conditions such as osteoarthritis, to life-threatening chronic diseases such as coronary heart disease, diabetes and certain cancers. The psychological consequences of obesity can range from lowered self-esteem to clinical depression. Despite the high prevalence of obesity and the many advances in our understanding of how it develops, current therapies have persistently failed to achieve long-term success. This review focuses on how fat mass can be reduced by altering the balance between energy intake and expenditure.

Publication types

  • Review

MeSH terms

  • Adipose Tissue, Brown / metabolism
  • Carrier Proteins / physiology
  • Energy Intake*
  • Energy Metabolism*
  • Humans
  • Hypothalamic Hormones / physiology
  • Leptin / physiology
  • Melanins / physiology
  • Neuropeptide Y / physiology
  • Obesity / metabolism
  • Obesity / therapy*
  • Pituitary Hormones / physiology
  • Pro-Opiomelanocortin / physiology
  • Receptor, Muscarinic M1
  • Receptors, Cell Surface*
  • Receptors, Corticotropin / physiology
  • Receptors, Leptin
  • Receptors, Melanocortin
  • Receptors, Muscarinic / physiology
  • Receptors, Pituitary Hormone / physiology
  • Transcription, Genetic

Substances

  • Carrier Proteins
  • Hypothalamic Hormones
  • Leptin
  • Melanins
  • Neuropeptide Y
  • Pituitary Hormones
  • Receptor, Muscarinic M1
  • Receptors, Cell Surface
  • Receptors, Corticotropin
  • Receptors, Leptin
  • Receptors, Melanocortin
  • Receptors, Muscarinic
  • Receptors, Pituitary Hormone
  • melanin-concentrating hormone receptor
  • Pro-Opiomelanocortin
  • melanin-concentrating hormone