Abstract
The occurrence of antinuclear antibodies (ANA) in an unselected population of pregnant women was studied by an indirect immunofluorescence method. Six women out of 116 were ANA-positive (5.2%), 2 of them having a moderately high titre (1:160 and 1:320) and 1 complement-fixing ANA. The antigenic specificity of ANA was anti-single-stranded DNA in 2 cases and RNAase-sensitive anti-extractable nuclear antigen in 1 case. Two of the ANA-positive women had pre-eclampsia laevis and 1 had a premature delivery. None of the infants of the ANA-positive women had symptoms of connective tissue disease. The occurrence of ANA among pregnant women was not significantly higher than among 70 non-pregnant female control subjects (7.1%).
MeSH terms
-
Adolescent
-
Adult
-
Antibodies, Antinuclear / analysis*
-
Antibodies, Antinuclear / genetics
-
Antibodies, Antinuclear / immunology
-
Complement Fixation Tests
-
DNA / immunology*
-
DNA, Single-Stranded / immunology*
-
Female
-
Finland
-
Fluorescent Antibody Technique
-
Hemagglutination Tests
-
Humans
-
Immunoglobulin G / analysis
-
Immunoglobulin G / genetics
-
Immunoglobulin G / immunology
-
Immunoglobulin M / analysis
-
Immunoglobulin M / genetics
-
Immunoglobulin M / immunology
-
Obstetric Labor, Premature / genetics
-
Obstetric Labor, Premature / immunology*
-
Parity
-
Pre-Eclampsia / genetics
-
Pre-Eclampsia / immunology*
-
Pregnancy / genetics
-
Pregnancy / immunology*
Substances
-
Antibodies, Antinuclear
-
DNA, Single-Stranded
-
Immunoglobulin G
-
Immunoglobulin M
-
DNA