[Vitamin D and autoimmunity. First part: Fundamental aspects]

Y Schoindre; B Terrier; J-E Kahn; D Saadoun; J-C Souberbielle; O Benveniste; Z Amoura; J-C Piette; P Cacoub; N Costedoat-Chalumeau

doi:10.1016/j.revmed.2011.11.009

[Vitamin D and autoimmunity. First part: Fundamental aspects]

Rev Med Interne. 2012 Feb;33(2):80-6. doi: 10.1016/j.revmed.2011.11.009. Epub 2011 Dec 27.

[Article in French]

Authors

Y Schoindre¹, B Terrier, J-E Kahn, D Saadoun, J-C Souberbielle, O Benveniste, Z Amoura, J-C Piette, P Cacoub, N Costedoat-Chalumeau

Affiliation

¹ Service de médecine interne, université Versailles Saint-Quentin-en-Yvelines, hôpital Foch, 40, rue Worth, 92151 Suresnes cedex, France. y.schoindre@hopital-foch.org

PMID: 22206605
DOI: 10.1016/j.revmed.2011.11.009

Abstract

The effects of vitamin D on calcium homeostasis and bone metabolism are well known. In recent years, suboptimal vitamin D status has been recognized as a pandemic. Meanwhile, extra-skeletal effects of vitamin D are becoming better documented, particularly its effects on immunity. The authors present their actions on myeloid dendritic cells, T cells, B cells, as well as on the synthesis of antimicrobial peptides and autophagy, and the potential beneficial effects in autoimmune and inflammatory diseases.

Publication types

English Abstract
Review

MeSH terms

Anti-Infective Agents / immunology
Antimicrobial Cationic Peptides / immunology
Autoimmune Diseases / drug therapy
Autoimmune Diseases / immunology
Autoimmune Diseases / physiopathology
Autoimmunity*
B-Lymphocytes / immunology
Bone and Bones / metabolism
Calcium / metabolism
Dendritic Cells / immunology
Homeostasis
Humans
T-Lymphocytes / immunology
Treatment Outcome
Vitamin D / immunology*
Vitamin D / metabolism
Vitamin D / therapeutic use
Vitamin D Deficiency / drug therapy
Vitamin D Deficiency / immunology*
Vitamin D Deficiency / physiopathology

Substances

Anti-Infective Agents
Antimicrobial Cationic Peptides
Vitamin D
Calcium