A large-scale replication study identifies TNIP1, PRDM1, JAZF1, UHRF1BP1 and IL10 as risk loci for systemic lupus erythematosus
…, E Svenungsson, L Padyukov, G Sturfelt, A Jönsen… - Nature …, 2009 - nature.com
Genome-wide association studies have recently identified at least 15 susceptibility loci for
systemic lupus erythematosus (SLE). To confirm additional risk loci, we selected SNPs from …
systemic lupus erythematosus (SLE). To confirm additional risk loci, we selected SNPs from …
Smoking and pre-existing organ damage reduce the efficacy of belimumab in systemic lupus erythematosus
I Parodis, C Sjöwall, A Jönsen, D Ramsköld… - Autoimmunity …, 2017 - Elsevier
Objectives Belimumab is the first biologic drug approved for Systemic Lupus Erythematosus
(SLE). Here, we aimed to investigate the effects of belimumab on clinical and serologic …
(SLE). Here, we aimed to investigate the effects of belimumab on clinical and serologic …
[PDF][PDF] Polymorphisms in the tyrosine kinase 2 and interferon regulatory factor 5 genes are associated with systemic lupus erythematosus
…, K Lindroos, AC Wiman, G Sturfelt, A Jönsen… - The American Journal of …, 2005 - cell.com
Systemic lupus erythematosus (SLE) is a complex systemic autoimmune disease caused by
both genetic and environmental factors. Genome scans in families with SLE point to multiple …
both genetic and environmental factors. Genome scans in families with SLE point to multiple …
Impact of glucocorticoids on the incidence of lupus-related major organ damage: a systematic literature review and meta-regression analysis of longitudinal …
…, S Jacobsen, JA James, A Jönsen… - Lupus science & …, 2021 - lupus.bmj.com
Objective In systemic lupus erythematosus (SLE), disease activity and glucocorticoid (GC)
exposure are known to contribute to irreversible organ damage. We aimed to examine the …
exposure are known to contribute to irreversible organ damage. We aimed to examine the …
Functional variants in the B-cell gene BANK1 are associated with systemic lupus erythematosus
…, I Gunnarsson, E Svenungsson, G Sturfelt, A Jönsen… - Nature …, 2008 - nature.com
Systemic lupus erythematosus (SLE) is a prototypical autoimmune disease characterized by
production of autoantibodies and complex genetic inheritance,,. In a genome-wide scan …
production of autoantibodies and complex genetic inheritance,,. In a genome-wide scan …
Gene–environment interactions in the aetiology of systemic lupus erythematosus
A Jönsen, AA Bengtsson, O Nived, L Truedsson… - …, 2007 - Taylor & Francis
Systemic lupus erythematosus (SLE) is a disease that displays a multitude of symptoms and
a vast array of autoantibodies. The disease course may vary substantially between patients …
a vast array of autoantibodies. The disease course may vary substantially between patients …
Incidence studies of systemic lupus erythematosus in Southern Sweden: increasing age, decreasing frequency of renal manifestations and good prognosis.
C Ståhl-Hallengren, A Jönsen, O Nived… - The Journal of …, 2000 - europepmc.org
Objective To identify all new cases of systemic lupus erythematosus (SLE) within a defined
area in Southern Sweden with validated methods of retrieval, and to compare 2 cohorts …
area in Southern Sweden with validated methods of retrieval, and to compare 2 cohorts …
Platelet transcriptional profile and protein expression in patients with systemic lupus erythematosus: up-regulation of the type I interferon system is strongly associated …
…, S Amisten, B Gullstrand, A Jönsen… - Blood, The Journal …, 2010 - ashpublications.org
Patients with systemic lupus erythematosus (SLE) have a markedly increased risk to
develop cardiovascular disease, and traditional cardiovascular risk factors fail to account for …
develop cardiovascular disease, and traditional cardiovascular risk factors fail to account for …
A risk haplotype of STAT4 for systemic lupus erythematosus is over-expressed, correlates with anti-dsDNA and shows additive effects with two risk alleles of …
…, G Sturfelt, AA Bengtsson, A Jönsen… - Human molecular …, 2008 - academic.oup.com
Systemic lupus erythematosus (SLE) is the prototype autoimmune disease where genes
regulated by type I interferon (IFN) are over-expressed and contribute to the disease …
regulated by type I interferon (IFN) are over-expressed and contribute to the disease …
Comprehensive evaluation of the genetic variants of interferon regulatory factor 5 (IRF5) reveals a novel 5 bp length polymorphism as strong risk factor for systemic …
…, E Svenungsson, G Sturfelt, A Jönsen… - Human molecular …, 2008 - academic.oup.com
We analyzed a comprehensive set of single-nucleotide polymorphisms (SNPs) and length
polymorphisms in the interferon regulatory factor 5 (IRF5) gene for their association with the …
polymorphisms in the interferon regulatory factor 5 (IRF5) gene for their association with the …