Interruption of the renin–angiotensin–aldosterone system has become a leading therapeutic
strategy in the treatment of chronic heart and kidney disease. Angiotensin-converting …

Glomerulonephritis (GN) is an important cause of morbidity and mortality in patients of all
ages throughout the world. Because these disorders are relatively rare, it is difficult to …

Results A total of 118,064 biopsies were included in this study. Patient age ranged from 30
to 79 years, and 45% of patients were women. On the basis of our meta-analysis, pain at the …

Background Exome sequencing is emerging as a first-line diagnostic method in some
clinical disciplines, but its usefulness has yet to be examined for most constitutional …

Background AKI is common among hospitalized patients with coronavirus disease 2019
(COVID-19) and is an independent risk factor for mortality. Although there are numerous …

IgA nephropathy (IgAN) is a progressive form of kidney disease defined by glomerular
deposition of IgA. Here we performed a genome-wide association study of 10,146 kidney …

Results The subjects included three patients with dense deposit disease (including one
patient with recurrent dense deposit disease in allograft) and three patients with C3 …

Background: National guidelines disagree on who should be screened for undiagnosed
diabetes. No existing diabetes risk score is highly generalizable or widely followed …

BACKGROUND: Elderly individuals with chronic kidney disease (CKD) have high rates of
comorbid conditions, including cardiovascular disease and its risk factors, and CKD-related …

Results The cohort included 371 men (60.7%) aged a median (interquartile range) 62 years
(52–69) with 10-year (5–15) duration of diabetes mellitus (DM). Median serum creatinine …