Autophagy in human health and disease
AMK Choi, SW Ryter, B Levine - New England Journal of …, 2013 - Mass Medical Soc
Autophagy in Human Health and Disease | NEJM Skip to main content NEJM Group Follow Us
Facebook Twitter Instagram YouTube LinkedIn Prepare to become a physician, build your …
Facebook Twitter Instagram YouTube LinkedIn Prepare to become a physician, build your …
Heme oxygenase-1/carbon monoxide: from basic science to therapeutic applications
SW Ryter, J Alam, AMK Choi - Physiological reviews, 2006 - journals.physiology.org
The heme oxygenases, which consist of constitutive and inducible isozymes (HO-1, HO-2),
catalyze the rate-limiting step in the metabolic conversion of heme to the bile pigments (ie …
catalyze the rate-limiting step in the metabolic conversion of heme to the bile pigments (ie …
Autophagy in major human diseases
Autophagy is a core molecular pathway for the preservation of cellular and organismal
homeostasis. Pharmacological and genetic interventions impairing autophagy responses …
homeostasis. Pharmacological and genetic interventions impairing autophagy responses …
Autophagy proteins regulate innate immune responses by inhibiting the release of mitochondrial DNA mediated by the NALP3 inflammasome
K Nakahira, JA Haspel, VAK Rathinam, SJ Lee… - Nature …, 2011 - nature.com
Autophagy, a cellular process for organelle and protein turnover, regulates innate immune
responses. Here we demonstrate that depletion of the autophagic proteins LC3B and beclin …
responses. Here we demonstrate that depletion of the autophagic proteins LC3B and beclin …
Carbon monoxide has anti-inflammatory effects involving the mitogen-activated protein kinase pathway
LE Otterbein, FH Bach, J Alam, M Soares, H Tao Lu… - Nature medicine, 2000 - nature.com
The stress-inducible protein heme oxygenase-1 provides protection against oxidative stress.
The anti-inflammatory properties of heme oxygenase-1 may serve as a basis for this …
The anti-inflammatory properties of heme oxygenase-1 may serve as a basis for this …
[HTML][HTML] Nrf2, a Cap'n'Collar transcription factor, regulates induction of the heme oxygenase-1 gene
J Alam, D Stewart, C Touchard, S Boinapally… - Journal of Biological …, 1999 - ASBMB
Stress response elements, which mediate induction of the mouse heme oxygenase-1 (HO-1)
gene by several agents, resemble the binding site for the activator protein-1 (Jun/Fos), Maf …
gene by several agents, resemble the binding site for the activator protein-1 (Jun/Fos), Maf …
Carbon monoxide generated by heme oxygenase 1 suppresses endothelial cell apoptosis
S Brouard, LE Otterbein, J Anrather… - The Journal of …, 2000 - rupress.org
Heme oxygenase 1 (HO-1) inhibits apoptosis by regulating cellular prooxidant iron. We now
show that there is an additional mechanism by which HO-1 inhibits apoptosis, namely by …
show that there is an additional mechanism by which HO-1 inhibits apoptosis, namely by …
Mechanisms of cell death in oxidative stress
SW Ryter, HP Kim, A Hoetzel, JW Park… - Antioxidants & redox …, 2007 - liebertpub.com
Reactive oxygen or nitrogen species (ROS/RNS) generated endogenously or in response to
environmental stress have long been implicated in tissue injury in the context of a variety of …
environmental stress have long been implicated in tissue injury in the context of a variety of …
Heme oxygenase: colors of defense against cellular stress
LE Otterbein, AMK Choi - American Journal of Physiology …, 2000 - journals.physiology.org
The discovery of the gaseous molecule nitric oxide in 1987 unraveled investigations on its
functional role in the pathogenesis of a wide spectrum of biological and pathological …
functional role in the pathogenesis of a wide spectrum of biological and pathological …
The NASA Twins Study: A multidimensional analysis of a year-long human spaceflight
INTRODUCTION To date, 559 humans have been flown into space, but long-duration (> 300
days) missions are rare (n= 8 total). Long-duration missions that will take humans to Mars …
days) missions are rare (n= 8 total). Long-duration missions that will take humans to Mars …