In the past decade, the emergence of machine learning (ML) applications has led to
significant advances towards implementation of personalised medicine approaches for …

Anecdotal evidence suggests that Coronavirus disease 2019 (COVID-19), caused by the
coronavirus SARS-CoV-2, exhibits differences in morbidity and mortality between sexes …

Zoonotic introduction of novel coronaviruses may encounter preexisting immunity in
humans. Using diverse assays for antibodies recognizing SARS-CoV-2 proteins, we …

Objective: The epidemiology of polyautoimmunity in Sjögren's syndrome (secondary
Sjögren's syndrome–sSS) is not well defined and has not been investigated before using a …

Suppressing inflammation has been the primary focus of therapies in autoimmune rheumatic
diseases (AIRDs), including rheumatoid arthritis and systemic lupus erythematosus …

Mammalian homologues of Drosophila melanogaster transient receptor potential (TRP) are
a large family of multimeric cation channels that act, or putatively act, as sensors of one or …

Background Systemic lupus erythematous (SLE) is a systemic autoimmune/inflammatory
condition. Approximately 15–20% of patients develop symptoms before their 18th birthday …

Type 1 interferons (IFN) are an antiviral cytokine family, important in juvenile onset systemic
lupus erythematosus (jSLE) which is more common in females, around puberty. We report …

Trial design We present a study protocol for a multi-centre, randomised, double-blind,
parallel-group, placebo-controlled trial that seeks to test the feasibility, acceptability and …

There is accumulating evidence that coronavirus disease 2019 (COVID-19) is a
hypercoagulable state. Reports of thrombotic events and autopsy findings of pulmonary …