User profiles for "author:Dag Leonard"
 | Dag LeonardUppsala University Verified email at medsci.uu.se Cited by 2041 |
Interferon pathway in SLE: one key to unlocking the mystery of the disease
L Rönnblom, D Leonard - Lupus science & medicine, 2019 - lupus.bmj.com
SLE is characterised by an activation of the interferon (IFN) system, which leads to an
increased expression of IFN-regulated genes. The reasons behind the IFN signature in SLE …
increased expression of IFN-regulated genes. The reasons behind the IFN signature in SLE …
DNA methylation mapping identifies gene regulatory effects in patients with systemic lupus erythematosus
J Imgenberg-Kreuz, JC Almlöf, D Leonard… - Annals of the …, 2018 - ard.bmj.com
Objectives Systemic lupus erythematosus (SLE) is a chronic autoimmune condition with
heterogeneous presentation and complex aetiology where DNA methylation changes are …
heterogeneous presentation and complex aetiology where DNA methylation changes are …
A single nucleotide polymorphism in the NCF1 gene leading to reduced oxidative burst is associated with systemic lupus erythematosus
LM Olsson, ÅC Johansson, B Gullstrand… - Annals of the …, 2017 - ard.bmj.com
Objectives Ncf1 polymorphisms leading to low production of reactive oxygen species (ROS)
are strongly associated with autoimmune diseases in animal models. The human NCF1 …
are strongly associated with autoimmune diseases in animal models. The human NCF1 …
High genetic risk score is associated with early disease onset, damage accrual and decreased survival in systemic lupus erythematosus
S Reid, A Alexsson, M Frodlund, D Morris… - Annals of the …, 2020 - ard.bmj.com
Objectives To investigate associations between a high genetic disease risk and disease
severity in patients with systemic lupus erythematosus (SLE). Methods Patients with SLE (n …
severity in patients with systemic lupus erythematosus (SLE). Methods Patients with SLE (n …
IFN-α production by plasmacytoid dendritic cells stimulated with RNA-containing immune complexes is promoted by NK cells via MIP-1β and LFA-1
Several systemic autoimmune diseases display a prominent IFN signature. This is caused
by a continuous IFN-α production by plasmacytoid dendritic cells (pDCs), which are …
by a continuous IFN-α production by plasmacytoid dendritic cells (pDCs), which are …
The STAT4 SLE risk allele rs7574865 [T] is associated with increased IL-12-induced IFN-γ production in T cells from patients with SLE
Objectives Genetic variants in the transcription factor STAT4 are associated with increased
susceptibility to systemic lupus erythematosus (SLE) and a more severe disease phenotype …
susceptibility to systemic lupus erythematosus (SLE) and a more severe disease phenotype …
[HTML][HTML] Sex differences in clinical presentation of systemic lupus erythematosus
JI Ramírez Sepúlveda, K Bolin, J Mofors… - Biology of sex …, 2019 - Springer
Objective Systemic lupus erythematosus (SLE) predominantly affects women, but previous
studies suggest that men with SLE present a more severe disease phenotype. In this study …
studies suggest that men with SLE present a more severe disease phenotype. In this study …
A STAT4 risk allele is associated with ischaemic cerebrovascular events and anti-phospholipid antibodies in systemic lupus erythematosus
E Svenungsson, J Gustafsson, D Leonard… - Annals of the …, 2010 - ard.bmj.com
Objective To investigate whether the risk allele for systemic lupus erythematosus (SLE) in
the signal transducer and activator of transcription factor 4 (STAT4) gene, defined by the …
the signal transducer and activator of transcription factor 4 (STAT4) gene, defined by the …
Four Systemic Lupus Erythematosus Subgroups, Defined by Autoantibodies Status, Differ Regarding HLA‐DRB1 Genotype Associations and Immunological and …
LM Diaz‐Gallo, V Oke, E Lundström… - ACR open …, 2022 - Wiley Online Library
Objective The heterogeneity of systemic lupus erythematosus (SLE) constitutes clinical and
therapeutical challenges. We therefore studied whether unrecognized disease subgroups …
therapeutical challenges. We therefore studied whether unrecognized disease subgroups …
[HTML][HTML] Whole-genome sequencing identifies complex contributions to genetic risk by variants in genes causing monogenic systemic lupus erythematosus
JC Almlöf, S Nystedt, D Leonard, ML Eloranta… - Human genetics, 2019 - Springer
Systemic lupus erythematosus (SLE, OMIM 152700) is a systemic autoimmune disease with
a complex etiology. The mode of inheritance of the genetic risk beyond familial SLE cases is …
a complex etiology. The mode of inheritance of the genetic risk beyond familial SLE cases is …