MicroRNAs as biomarkers in rheumatic diseases

I Alevizos, GG Illei - Nature Reviews Rheumatology, 2010 - nature.com
MicroRNAs (miRNAs) are endogenous, noncoding, single-stranded RNAs of 19–25
nucleotides in length. They regulate gene expression and are important in a wide range of …

Pathogenesis of Sjögren's syndrome

NP Nikolov, GG Illei - Current opinion in rheumatology, 2009 - journals.lww.com
Recent discoveries from studies in patients with Sjögren's syndrome and animal models
suggest a complex interplay between genetic factors, environmental and stochastic events …

Cytokines in Sjögren's syndrome

N Roescher, PP Tak, GG Illei - Oral diseases, 2009 - Wiley Online Library
Cytokines play a central role in the regulation of immunity and are often found to be
deregulated in autoimmune diseases. Sjögren's syndrome is a chronic autoimmune disease …

[HTML][HTML] The majority of microRNAs detectable in serum and saliva is concentrated in exosomes

A Gallo, M Tandon, I Alevizos, GG Illei - PloS one, 2012 - journals.plos.org
There is an increasing interest in using microRNAs (miRNA) as biomarkers in autoimmune
diseases. They are easily accessible in many body fluids but it is controversial if they are …

Exosomes from human saliva as a source of microRNA biomarkers

A Michael, SD Bajracharya, PST Yuen, H Zhou… - Oral …, 2010 - Wiley Online Library
Objective: The aim of this study was to examine the presence of microRNAs (miRNAs) within
exosomes isolated from human saliva and to optimize and test methods for successful …

[PDF][PDF] Anifrolumab, an anti–interferon‐α receptor monoclonal antibody, in moderate‐to‐severe systemic lupus erythematosus

R Furie, M Khamashta, JT Merrill… - Arthritis & …, 2017 - Wiley Online Library
Objective To assess the efficacy and safety of anifrolumab, a type I interferon (IFN) receptor
antagonist, in a phase IIb, randomized, double‐blind, placebo‐controlled study of adults with …

Identification and characterization of circulating human transitional B cells

GP Sims, R Ettinger, Y Shirota, CH Yarboro, GG Illei… - Blood, 2005 - ashpublications.org
Murine B-cell development begins in bone marrow and results in the generation of immature
transitional B cells that transit to the spleen to complete their maturation. It remains unclear …

A short course of BG9588 (anti–CD40 ligand antibody) improves serologic activity and decreases hematuria in patients with proliferative lupus glomerulonephritis

DT Boumpas, R Furie, S Manzi, GG Illei… - Arthritis & …, 2003 - Wiley Online Library
Abstract Objective CD40–CD40 ligand (CD40L) interactions play a significant role in the
production of autoantibodies and tissue injury in lupus nephritis. We performed an open …

Combination therapy with pulse cyclophosphamide plus pulse methylprednisolone improves long-term renal outcome without adding toxicity in patients with lupus …

GG Illei, HA Austin III, M Crane, L Collins… - Annals of internal …, 2001 - acpjournals.org
Background: Controlled trials in lupus nephritis have demonstrated that cyclophosphamide
therapy is superior to corticosteroid therapy alone. The long-term effectiveness and side …

Deficient CD4+ CD25high T regulatory cell function in patients with active systemic lupus erythematosus

X Valencia, C Yarboro, G Illei… - The Journal of …, 2007 - journals.aai.org
Abstract CD4+ CD25+ T regulatory cells (Tregs) play an essential role in maintaining
immunologic homeostasis and preventing autoimmunity. Systemic lupus erythematosus …