INTRODUCTION Brain disorders may exhibit shared symptoms and substantial
epidemiological comorbidity, inciting debate about their etiologic overlap. However, detailed …

Migraine is a disabling primary headache disorder that directly affects more than one billion
people worldwide. Despite its widespread prevalence, migraine remains under-diagnosed …

Previous studies have suggested that migraine is a risk factor for brain lesions, but
methodological issues hampered drawing definite conclusions. Therefore, we initiated the …

Genes for familial hemiplegic migraine (FHM) and episodic ataxia type-2 (EA-2) have been
mapped to chromosome 19p13. We characterized a brain-specific P/Q-type Ca 2+ channel …

ContextClinical series have suggested an increased prevalence of cerebral infarction and
white matter lesions (WMLs) in migraine patients. It is not known whether these lesions are …

Migraine is a debilitating neurological disorder affecting around one in seven people
worldwide, but its molecular mechanisms remain poorly understood. There is some debate …

Objective: To describe the distribution of migraine and its subtypes in the general
population. Background: Previous population-based studies are limited by small samples or …

Migraine is a common, heterogeneous and heritable neurological disorder. Its
pathophysiology is incompletely understood, and its genetic influences at the population …

Autosomal dominant retinal vasculopathy with cerebral leukodystrophy is a microvascular
endotheliopathy with middle-age onset. In nine families, we identified heterozygous C …

Migraine is a common, disabling, and undertreated episodic brain disorder that is more
common in women than in men. Unbiased genome-wide association studies have identified …