The molecular and cellular processes that lead to renal damage and to the heterogeneity of
lupus nephritis (LN) are not well understood. We applied single-cell RNA sequencing …

The placenta and decidua interact dynamically to enable embryonic and fetal development.
Here, we report single-cell RNA sequencing of 14,341 and 6754 cells from first-trimester …

Background Atopic dermatitis (AD) is a prevalent inflammatory skin disease with a complex
pathogenesis involving immune cell and epidermal abnormalities. Despite whole tissue …

MicroRNAs (miRNAs) play crucial roles in regulating gene expression in many cellular
contexts. Deregulation of miRNAs has been implicated in a number of disease conditions …

Lupus nephritis is a leading cause of mortality among systemic lupus erythematosus (SLE)
patients, and its heterogeneous nature poses a significant challenge to the development of …

The vertebrate-conserved RNA-binding protein DND1 is required for the survival of
primordial germ cells (PGCs), as well as the suppression of germ cell tumours in mice …

Emerging urinary biomarkers continue to show promise in evaluating lupus nephritis (LN).
Here, we screen urine from active LN patients for 1129 proteins using an aptamer-based …

Abstract RNA-sequencing (RNA-seq) is a technique to determine the order of nucleotides in
an RNA segment. Modern sequencing platforms simultaneously sequence millions of RNA …

Aims Investigating human heart development and applying this to deviations resulting in
disease is incomplete without molecular characterization of the cell types required for …

Characteristic small RNA biogenesis processing patterns are used for the discovery of novel
microRNAs (miRNAs) from next-generation sequencing data. Here, we highlight and …