Genome-wide association studies have recently identified at least 15 susceptibility loci for
systemic lupus erythematosus (SLE). To confirm additional risk loci, we selected SNPs from …

Approximately 1.5 billion people worldwide are overweight or affected by obesity, and are at
risk of developing type 2 diabetes, cardiovascular disease and related metabolic and …

Background Obesity is a major health problem that is determined by interactions between
lifestyle and environmental and genetic factors. Although associations between several …

Epigenetic modifications such as DNA methylation play a key role in gene regulation and
disease susceptibility. However, little is known about the genome-wide frequency …

Systemic lupus erythematosus (SLE) is an autoimmune disease with marked gender and
ethnic disparities. We report a large transancestral association study of SLE using …

Obesity is an important component of the pathophysiology of chronic diseases. Identifying
epigenetic modifications associated with elevated adiposity, including DNA methylation …

Primary Sjögren's syndrome (pSS) is a chronic autoimmune rheumatic disease
characterized by inflammation of exocrine glands, mainly salivary and lacrimal glands. In …

Background—Epigenetic mechanisms might be involved in the regulation of interindividual
lipid level variability and thus may contribute to the cardiovascular risk profile. The aim of this …

An age-dependent association between variation at the FTO locus and BMI in children has
been suggested. We meta-analyzed associations between the FTO locus (rs9939609) and …

Objectives Increasing evidence suggests an epigenetic contribution to the pathogenesis of
autoimmune diseases, including primary Sjögren's Syndrome (pSS). The aim of this study …