User profiles for "author:Joseph Vijai"

Vijai Joseph

Memorial Sloan Kettering Cancer Center, New York
Verified email at mskcc.org
Cited by 15076

[HTML][HTML] Inherited DNA-repair gene mutations in men with metastatic prostate cancer

CC Pritchard, J Mateo, MF Walsh… - … England Journal of …, 2016 - Mass Medical Soc
Background Inherited mutations in DNA-repair genes such as BRCA2 are associated with
increased risks of lethal prostate cancer. Although the prevalence of germline mutations in …

Integrative clinical genomics of metastatic cancer

DR Robinson, YM Wu, RJ Lonigro, P Vats, E Cobain… - Nature, 2017 - nature.com
Metastasis is the primary cause of cancer-related deaths. Although The Cancer Genome
Atlas has sequenced primary tumour types obtained from surgical resections, much less …

Prospective genomic profiling of prostate cancer across disease states reveals germline and somatic alterations that may affect clinical decision making

W Abida, J Armenia, A Gopalan, R Brennan… - JCO precision …, 2017 - ascopubs.org
Purpose A long natural history and a predominant osseous pattern of metastatic spread are
impediments to the adoption of precision medicine in patients with prostate cancer. To …

[HTML][HTML] Microsatellite instability is associated with the presence of Lynch syndrome pan-cancer

A Latham, P Srinivasan, Y Kemel, J Shia… - Journal of clinical …, 2019 - ncbi.nlm.nih.gov
PURPOSE Microsatellite instability (MSI) and/or mismatch repair deficiency (MMR-D) testing
has traditionally been performed in patients with colorectal (CRC) and endometrial cancer …

Mutation detection in patients with advanced cancer by universal sequencing of cancer-related genes in tumor and normal DNA vs guideline-based germline testing

D Mandelker, L Zhang, Y Kemel, ZK Stadler, V Joseph… - Jama, 2017 - jamanetwork.com
Importance Guidelines for cancer genetic testing based on family history may miss clinically
actionable genetic changes with established implications for cancer screening or …

A locus on 19p13 modifies risk of breast cancer in BRCA1 mutation carriers and is associated with hormone receptor–negative breast cancer in the general …

AC Antoniou, X Wang, ZS Fredericksen, L McGuffog… - Nature …, 2010 - nature.com
Germline BRCA1 mutations predispose to breast cancer. To identify genetic modifiers of this
risk, we performed a genome-wide association study in 1,193 individuals with BRCA1 …

A recurrent germline PAX5 mutation confers susceptibility to pre-B cell acute lymphoblastic leukemia

S Shah, KA Schrader, E Waanders, AE Timms, J Vijai… - Nature …, 2013 - nature.com
Somatic alterations of the lymphoid transcription factor gene PAX5 (also known as BSAP)
are a hallmark of B cell precursor acute lymphoblastic leukemia (B-ALL),,, but inherited …

Germline variants in targeted tumor sequencing using matched normal DNA

KA Schrader, DT Cheng, V Joseph, M Prasad… - JAMA …, 2016 - jamanetwork.com
Importance Tumor genetic sequencing identifies potentially targetable genetic alterations
with therapeutic implications. Analysis has concentrated on detecting tumor-specific …

Identification of six new susceptibility loci for invasive epithelial ovarian cancer

KB Kuchenbaecker, SJ Ramus, J Tyrer, A Lee… - Nature …, 2015 - nature.com
Genome-wide association studies (GWAS) have identified 12 epithelial ovarian cancer
(EOC) susceptibility alleles. The pattern of association at these loci is consistent in BRCA1 …

Mutational spectrum in a worldwide study of 29,700 families with BRCA1 or BRCA2 mutations

TR Rebbeck, TM Friebel, E Friedman… - Human …, 2018 - Wiley Online Library
The prevalence and spectrum of germline mutations in BRCA1 and BRCA2 have been
reported in single populations, with the majority of reports focused on White in Europe and …