Background Gene expression studies of peripheral blood mononuclear cells from patients
with systemic lupus erythematosus (SLE) have demonstrated a type I interferon signature …

The efficacy of influenza vaccination in patients treated with rituximab is a clinically important
question. Rheumatology clinics are populated with patients receiving rituximab for a broad …

Background & Aims Very early onset inflammatory bowel disease (VEO-IBD), IBD diagnosed
at 5 years of age or younger, frequently presents with a different and more severe phenotype …

Systemic lupus erythematosus (SLE) is a polygenic disorder affecting approximately 1 in
1000 adults. Recent data have implicated interferons (IFN) in the pathogenesis, and the …

Among previously healthy children with severe influenza, the mechanisms leading to
increased pathology are not understood. We hypothesized that children with severe …

The pioneer transcription factor (TF) PU. 1 controls hematopoietic cell fate by decompacting
stem cell heterochromatin and allowing nonpioneer TFs to enter otherwise inaccessible …

Background Insight into the pathogenesis of very early onset-inflammatory bowel disease
(VEO-IBD) has expanded through the identification of causative monogenic defects detected …

Objective To understand the roles of microRNAs (miRNAs) in proliferative lupus nephritis
(LN). Methods A high‐throughput analysis of the miRNA pattern of the kidneys of LN patients …

Histone acetylation modulates gene expression and has been described as increased in
systemic lupus erythematosus (SLE). We investigated interferon regulatory factor 1 (IRF1) …

Background Children with very early-onset inflammatory bowel disease (VEO-IBD), those
diagnosed at less than 5 years of age, are a unique population. A subset of these patients …