Mouse models of lupus: what they tell us and what they don't

ML Richard, G Gilkeson - Lupus science & medicine, 2018 - lupus.bmj.com
Lupus is a complex heterogeneous disease characterised by autoantibody production and
immune complex deposition followed by damage to target tissues. Animal models of human …

The Fli-1 transcription factor regulates the expression of CCL5/RANTES

ML Lennard Richard, S Sato, E Suzuki… - The Journal of …, 2014 - journals.aai.org
The friend leukemia insertion site 1 (Fli-1) transcription factor, an Ets family member, is
implicated in the pathogenesis of systemic lupus erythematosus in human patients and …

A critical role of the transcription factor fli‐1 in murine lupus development by regulation of interleukin‐6 expression

S Sato, M Lennard Richard, D Brandon… - Arthritis & …, 2014 - Wiley Online Library
Objective The Fli‐1 transcription factor is implicated in the pathogenesis of systemic lupus
erythematosus (SLE), both in humans and in animal models. Dysregulation of interleukin‐6 …

Expression of GM-CSF is regulated by Fli-1 transcription factor, a potential drug target

X Wang, M Lennard Richard, P Li, B Henry… - The Journal of …, 2021 - journals.aai.org
Friend leukemia virus integration 1 (Fli-1) is an ETS transcription factor and a critical
regulator of inflammatory mediators, including MCP-1, CCL5, IL-6, G-CSF, CXCL2, and …

[HTML][HTML] Role of the transcription factor Fli-1 on the CXCL10/CXCR3 Axis

X Wang, ML Richard, TK Nowling… - Frontiers in …, 2023 - frontiersin.org
The transcription factor Fli-1, a member of the ETS family of transcription factors, is
implicated in the pathogenesis of lupus disease. Reduced Fli-1 expression in lupus mice …

Acetylation impacts Fli‐1‐driven regulation of granulocyte colony stimulating factor

ML Lennard Richard, D Brandon, N Lou… - European journal of …, 2016 - Wiley Online Library
Fli‐1 has emerged as a critical regulator of inflammatory mediators, including MCP‐1, CCL5,
and IL‐6. The cytokine, granulocyte colony stimulating factor (G‐CSF) regulates neutrophil …

Novel mechanism for estrogen receptor alpha modulation of murine lupus

MA Cunningham, ML Richard, JR Wirth, JL Scott… - Journal of …, 2019 - Elsevier
Female sex is a risk factor for lupus. Sex hormones, sex chromosomes and hormone
receptors are implicated in the pathogenic pathways in lupus. Estrogen receptor alpha …

Conditional knockout of oestrogen receptor alpha in CD11c+ cells impacts female survival and inflammatory cytokine profile in murine lupus

ML Lennard Richard, JR Wirth, A Khatiwada… - …, 2022 - Wiley Online Library
Oestrogen and oestrogen receptor alpha (ERα) have been implicated in systemic lupus
erythematosus pathogenesis. ERα signalling influences dendritic cell (DC) development …

180 Examining the transcriptional impact of liganded estrogen receptor alpha in the inflammatory milieu of systemic lupus erythematosus

ML Richard, MA Cunningham, B Tsao, GS Gilkeson - 2019 - lupus.bmj.com
Background Systemic lupus erythematosus (SLE) disproportionally affects females (9: 1)
over males. Despite significant research effort, the exact mechanisms behind this compelling …

Identification of Fli-1 as a novel regulator of the inflammatory chemokine CCL5/RANTES (CCR5P. 253)

M Lennard Richard, S Sato, E Suzuki… - The Journal of …, 2014 - journals.aai.org
The Fli-1 transcription factor is implicated in the pathogenesis of systemic lupus
erythematosus (SLE) in both human patients and murine models of lupus. Lupus-prone mice …