Abstract The importance of Jak-Stat pathway signaling in regulating cytokine-dependent
gene expression and cellular development/survival is well established. Nevertheless …

The Janus kinase (JAK)–signal transducer of activators of transcription (STAT) pathway is
now recognized as an evolutionarily conserved signaling pathway employed by diverse …

The discovery of cytokines as key drivers of immune-mediated diseases has spurred efforts
to target their associated signalling pathways. Janus kinases (JAKs) are essential signalling …

Autosomal dominant periodic fever syndromes are characterized by unexplained episodes
of fever and severe localized inflammation. In seven affected families, we found six different …

Background The study of autoinflammatory diseases has uncovered mechanisms
underlying cytokine dysregulation and inflammation. Methods We analyzed the DNA of an …

Differentiation of naive CD4+ T cells into IFN-γ-producing T helper 1 (TH1) cells is pivotal for
protective immune responses against intracellular pathogens. T-bet, a recently discovered …

Background Autoinflammatory diseases manifest inflammation without evidence of infection,
high-titer autoantibodies, or autoreactive T cells. We report a disorder caused by mutations …

The Janus kinase/signal transduction and activator of transcription (JAK–STAT) signaling
pathway is implicated in the pathogenesis of inflammatory and autoimmune diseases …

Background We observed a syndrome of intermittent fevers, early-onset lacunar strokes and
other neurovascular manifestations, livedoid rash, hepatosplenomegaly, and systemic …

Behçet's disease is a genetically complex disease of unknown etiology characterized by
recurrent inflammatory attacks affecting the orogenital mucosa, eyes and skin. We performed …