Epigenetic dysregulation of ACE2 and interferon-regulated genes might suggest increased COVID-19 susceptibility and severity in lupus patients

AH Sawalha, M Zhao, P Coit, Q Lu - Clinical Immunology, 2020 - Elsevier
Infection caused by SARS-CoV-2 can result in severe respiratory complications and death.
Patients with a compromised immune system are expected to be more susceptible to a …

Genome-wide DNA methylation study suggests epigenetic accessibility and transcriptional poising of interferon-regulated genes in naive CD4+ T cells from lupus …

P Coit, M Jeffries, N Altorok, MG Dozmorov… - Journal of …, 2013 - Elsevier
Systemic lupus erythematosus is an autoimmune disease characterized by multi-system
involvement and autoantibody production. Abnormal T cell DNA methylation and type-I …

[PDF][PDF] Identification of multiple genetic susceptibility loci in Takayasu arteritis

G Saruhan-Direskeneli, T Hughes, K Aksu… - The American Journal of …, 2013 - cell.com
Takayasu arteritis is a rare inflammatory disease of large arteries. The etiology of Takayasu
arteritis remains poorly understood, but genetic contribution to the disease pathogenesis is …

Genome‐wide DNA methylation patterns in naive CD4+ T cells from patients with primary Sjögren's syndrome

N Altorok, P Coit, T Hughes, KA Koelsch… - Arthritis & …, 2014 - Wiley Online Library
Objective Primary Sjögren's syndrome (SS) is a systemic autoimmune disease with
incompletely understood etiology. This study was undertaken to investigate the role of …

Genome-wide DNA methylation analysis in dermal fibroblasts from patients with diffuse and limited systemic sclerosis reveals common and subset-specific DNA …

N Altorok, PS Tsou, P Coit, D Khanna… - Annals of the rheumatic …, 2015 - ard.bmj.com
Background The aetiology of systemic sclerosis (SSc) is not clear, but there is an emerging
evidence of gene-specific epigenetic dysregulation in the pathogenesis of SSc. Methods We …

Epigenome profiling reveals significant DNA demethylation of interferon signature genes in lupus neutrophils

P Coit, S Yalavarthi, M Ognenovski, W Zhao… - Journal of …, 2015 - Elsevier
Recent evidence suggests that neutrophils play an important role in the pathogenesis of
lupus. The goal of this study was to characterize the epigenetic architecture, by studying the …

Identification of multiple independent susceptibility loci in the HLA region in Behcet's disease

T Hughes, P Coit, A Adler, V Yilmaz, K Aksu… - Nature …, 2013 - nature.com
Behçet's disease is an inflammatory disease characterized by recurrent oral and genital
ulcers and significant organ involvement. Localizing the genetic association between HLA …

The human microbiome in rheumatic autoimmune diseases: A comprehensive review

P Coit, AH Sawalha - Clinical Immunology, 2016 - Elsevier
The human microbiome consists of the total diversity of microbiota and their genes. High-
throughput sequencing has allowed for inexpensive and rapid evaluation of taxonomic …

Renal involvement in lupus is characterized by unique DNA methylation changes in naïve CD4+ T cells

P Coit, P Renauer, MA Jeffries, JT Merrill… - Journal of …, 2015 - Elsevier
Systemic lupus erythematosus is a multi-system disease characterized by wide-spread DNA
methylation changes. To identify epigenetic susceptibility loci for lupus nephritis, genome …

Sequencing of 16S rRNA reveals a distinct salivary microbiome signature in Behcet's disease

P Coit, G Mumcu, F Ture-Ozdemir, AU Unal, U Alpar… - Clinical …, 2016 - Elsevier
Behçet's disease (BD) is characterized by recurrent oro-genital ulcers, mucocutaneous
lesions, and serious organ involvement. We investigated the salivary microbiome in BD …