During the past 10 years, preclinical studies implicating sustained androgen receptor (AR)
signalling as the primary driver of castration-resistant prostate cancer (CRPC) have led to …

The original central fatigue hypothesis suggested that an exercise-induced increase in
extracellular serotonin concentrations in several brain regions contributed to the …

Background In order for patients to adhere to healthcare advice, it is essential that they are
able to recall this following a consultation. Although psychological research exists which …

Metastatic prostate cancer is treated with drugs that antagonize androgen action, but most
patients progress to a more aggressive form of the disease called castration-resistant …

Purpose The purpose of this study was to evaluate the validity of the CSA activity monitor as
a measure of children's physical activity using energy expenditure (EE) as a criterion …

Some cancers evade targeted therapies through a mechanism known as lineage plasticity,
whereby tumor cells acquire phenotypic characteristics of a cell lineage whose survival no …

Androgen receptor (AR) splice variants lacking the ligand binding domain (ARVs), originally
isolated from prostate cancer cell lines derived from a single patient, are detected in normal …

We demonstrate that the androgen receptor (AR) regulates a transcriptional program of DNA
repair genes that promotes prostate cancer radioresistance, providing a potential …

The second-generation antiandrogen enzalutamide was recently approved for patients with
castration-resistant prostate cancer. Despite its success, the duration of response is often …

We have measured the surface tensions, with use of a ring tensiometer, of a series of closely
related ionic liquids [C n mim][X] where [C n mim] represents the 1-C n H 2 n+ 1-3 …