COVID-19 and autoimmune diseases

Y Liu, AH Sawalha, Q Lu - Current opinion in rheumatology, 2021 - journals.lww.com
We present a review of the association between COVID-19 and autoimmune diseases,
focusing on similarities in immune responses, cross-reactivity of SARS-CoV-2, the …

Epigenetics in health and disease

L Zhang, Q Lu, C Chang - Epigenetics in allergy and autoimmunity, 2020 - Springer
Epigenetic mechanisms, which include DNA methylation, histone modification, and
microRNA (miRNA), can produce heritable phenotypic changes without a change in DNA …

Induced regulatory T cells: their development, stability, and applications

M Kanamori, H Nakatsukasa, M Okada, Q Lu… - Trends in …, 2016 - cell.com
Regulatory T (Treg) cells, as central mediators of immune suppression, play crucial roles in
many facets of immune systems. The transcription factor Foxp3 has been characterized as a …

Consensus of Chinese experts on protection of skin and mucous membrane barrier for health‐care workers fighting against coronavirus disease 2019

Y Yan, H Chen, L Chen, B Cheng, P Diao… - Dermatologic …, 2020 - Wiley Online Library
Health professions preventing and controlling Coronavirus Disease 2019 are prone to skin
and mucous membrane injury, which may cause acute and chronic dermatitis, secondary …

Demethylation of CD40LG on the inactive X in T cells from women with lupus

Q Lu, A Wu, L Tesmer, D Ray, N Yousif… - The journal of …, 2007 - journals.aai.org
Why systemic lupus erythematosus primarily affects women is unknown. Recent evidence
indicates that human lupus is an epigenetic disease characterized by impaired T cell DNA …

MicroRNA‐126 regulates DNA methylation in CD4+ T cells and contributes to systemic lupus erythematosus by targeting DNA methyltransferase 1

S Zhao, Y Wang, Y Liang, M Zhao, H Long… - Arthritis & …, 2011 - Wiley Online Library
Objective To identify microRNA genes with abnormal expression in the CD4+ T cells of
patients with systemic lupus erythematosus (SLE) and to determine the role of microRNA …

Epigenetic dysregulation of ACE2 and interferon-regulated genes might suggest increased COVID-19 susceptibility and severity in lupus patients

AH Sawalha, M Zhao, P Coit, Q Lu - Clinical Immunology, 2020 - Elsevier
Infection caused by SARS-CoV-2 can result in severe respiratory complications and death.
Patients with a compromised immune system are expected to be more susceptible to a …

The inflammatory response in psoriasis: a comprehensive review

Y Deng, C Chang, Q Lu - Clinical reviews in allergy & immunology, 2016 - Springer
Psoriasis is a chronic inflammatory autoimmune disease characterized by an excessively
aberrant hyperproliferation of keratinocytes. The pathogenesis of psoriasis is complex and …

TLR2 and TLR4 in autoimmune diseases: a comprehensive review

Y Liu, H Yin, M Zhao, Q Lu - Clinical reviews in allergy & immunology, 2014 - Springer
Autoimmune diseases are immune disorders characterized by T cell hyperactivity and B cell
overstimulation leading to overproduction of autoantibodies. Although the pathogenesis of …

Demethylation of ITGAL (CD11a) regulatory sequences in systemic lupus erythematosus

Q Lu, M Kaplan, D Ray, D Ray, S Zacharek… - Arthritis & …, 2002 - Wiley Online Library
Objective Inhibition of T cell DNA methylation causes autoreactivity in vitro and a lupus‐like
disease in vivo, suggesting that T cell DNA hypomethylation may contribute to autoimmunity …