Exosomes from red blood cell units bind to monocytes and induce proinflammatory cytokines, boosting T-cell responses in vitro

A Danesh, HC Inglis, RP Jackman, S Wu… - Blood, The Journal …, 2014 - ashpublications.org
Extracellular vesicles (EVs) are small, double membrane vesicles derived from leukocytes,
platelets, and cells of other tissues under physiological or pathological conditions …

Transfusion-associated microchimerism: the hybrid within

EM Bloch, RP Jackman, TH Lee, MP Busch - Transfusion medicine reviews, 2013 - Elsevier
Microchimerism, the coexistence of genetically disparate populations of cells in a receptive
host, is well described in both clinical and physiological settings, including transplantation …

[HTML][HTML] Frequent detection but lack of infectivity of SARS-CoV-2 RNA in presymptomatic, infected blood donor plasma

P Saá, RV Fink, S Bakkour, J Jin… - The Journal of …, 2022 - Am Soc Clin Investig
Respiratory viruses such as influenza do not typically cause viremia; however, SARS-CoV-2
has been detected in the blood of COVID-19 patients with mild and severe symptoms …

Blood donor obesity is associated with changes in red blood cell metabolism and susceptibility to hemolysis in cold storage and in response to osmotic and oxidative …

K Hazegh, F Fang, MD Bravo, JQ Tran… - …, 2021 - Wiley Online Library
Background Obesity is a global pandemic characterized by multiple comorbidities, including
cardiovascular and metabolic diseases. The aim of this study was to define the associations …

Low-level HLA antibodies do not predict platelet transfusion failure in TRAP study participants

RP Jackman, X Deng, D Bolgiano… - Blood, The Journal …, 2013 - ashpublications.org
Abstract In the Trial to Reduce Alloimmunization to Platelets (TRAP) study, 101 of 530
participants became refractory to platelet transfusions without evidence of HLA or human …

Distinct roles of trauma and transfusion in induction of immune modulation after injury

RP Jackman, GH Utter, MO Muench, JW Heitman… - …, 2012 - Wiley Online Library
BACKGROUND: Trauma and transfusion can both alter immunity, and while transfusions are
common among traumatically injured patients, few studies have examined their combined …

[HTML][HTML] Bidirectionality between cardiometabolic diseases and COVID-19: Role of humoral immunity

AY Elaine, RP Jackman, MJ Glesby, KMV Narayan - Advances in Nutrition, 2023 - Elsevier
Cardiometabolic diseases and abnormalities have recently emerged as independent risk
factors of coronavirus disease 2019 (COVID-19) severity, including hospitalizations, invasive …

Leukoreduction and ultraviolet treatment reduce both the magnitude and the duration of the HLA antibody response

RP Jackman, X Deng, D Bolgiano, GH Utter… - …, 2014 - Wiley Online Library
Background Both leukoreduction and ultraviolet (UV) light treatment of blood products have
been shown to reduce the incidence of HLA antibody development in recipients, but the …

IMMUNOHEMATOLOGY: Understanding loss of donor white blood cell immunogenicity after pathogen reduction: mechanisms of action in ultraviolet illumination and …

RP Jackman, JW Heitman, S Marschner… - …, 2009 - Wiley Online Library
BACKGROUND: Donor white blood cells (WBCs) present in transfusion products can lead to
immune sequelae such as production of HLA antibodies or graft‐versus‐host disease in …

Increased alloreactive and autoreactive antihuman leucocyte antigen antibodies associated with systemic lupus erythematosus and rheumatoid arthritis

RP Jackman, GI Cruz, J Nititham, DJ Triulzi… - Lupus science & …, 2018 - lupus.bmj.com
Objectives Rheumatoid arthritis (RA) and systemic lupus erythematosus (SLE)
disproportionately affect women during and following childbearing years. Antihuman …