OBJECTIVE: Although osteoarthritis (OA) is considered a non-inflammatory condition, it is
widely accepted that synovial inflammation is a feature of OA. However, the role of immune …

Objective To investigate the association between weight or body mass index (BMI) and the
development of hand osteoarthritis. Methods Systematic review of observational studies …

The Study Group for Risk Factors for Rheumatoid Arthritis was established by the EULAR
Standing Committee on Investigative Rheumatology to facilitate research into the preclinical …

Objectives To provide an update of the European League Against Rheumatism (EULAR)
rheumatoid arthritis (RA) management recommendations to account for the most recent …

Abstract Objective The 1987 American College of Rheumatology (ACR; formerly, the
American Rheumatism Association) classification criteria for rheumatoid arthritis (RA) have …

A major challenge in human genetics is to devise a systematic strategy to integrate disease-
associated variants with diverse genomic and biological data sets to provide insight into …

To identify new genetic risk factors for rheumatoid arthritis, we conducted a genome-wide
association study meta-analysis of 5,539 autoantibody-positive individuals with rheumatoid …

Foxp3 plays a key role in CD4+ CD25+ Treg cell function in mice and represents a specific
marker for these cells. Despite the strong association between FOXP3 expression and …

Background To assess the genetic influence on cytokine production and its contribution to
fatal outcome, we determined the capacity to produce tumour necrosis factor-α (TNFα) and …

Objective The main genetic risk factor for rheumatoid arthritis (RA), the HLA region, has
been known for 25 years. Previous research has demonstrated, within the RA population, an …