Trojan horses: drug culprits associated with antineutrophil cytoplasmic autoantibody (ANCA) vasculitis

WF Pendergraft III, JL Niles - Current opinion in rheumatology, 2014 - journals.lww.com
Hydralazine, minocycline, propylthiouracil and levamisole-adulterated cocaine use should
be closely considered in any patient where ANCA vasculitis is entertained given the wide …

Nephrotoxic effects of common and emerging drugs of abuse

WF Pendergraft III, LC Herlitz… - Clinical journal of the …, 2014 - journals.lww.com
The kidneys can be injured in diverse ways by many drugs, both legal and illegal. Novel
associations and descriptions of nephrotoxic effects of common and emerging drugs of …

The immune cell landscape in kidneys of patients with lupus nephritis

A Arazi, DA Rao, CC Berthier, A Davidson, Y Liu… - Nature …, 2019 - nature.com
Lupus nephritis is a potentially fatal autoimmune disease for which the current treatment is
ineffective and often toxic. To develop mechanistic hypotheses of disease, we analyzed …

Autoimmunity is triggered by cPR-3 (105–201), a protein complementary to human autoantigen proteinase-3

WF Pendergraft III, GA Preston, RR Shah, A Tropsha… - Nature medicine, 2004 - nature.com
It remains unclear how and why autoimmunity occurs. Here we show evidence for a
previously unrecognized and possibly general mechanism of autoimmunity. This new …

[HTML][HTML] A randomized, controlled double-blind study comparing the efficacy and safety of dose-ranging voclosporin with placebo in achieving remission in patients …

BH Rovin, N Solomons, WF Pendergraft III… - Kidney international, 2019 - Elsevier
Calcineurin inhibitors added to standard-of-care induction therapy for lupus nephritis (LN)
may increase complete renal remission (CRR) rates. The AURA-LV study tested the novel …

Phase II randomized trial of rituximab plus cyclophosphamide followed by belimumab for the treatment of lupus nephritis

Y Atisha‐Fregoso, S Malkiel, KM Harris… - Arthritis & …, 2021 - Wiley Online Library
Objective To assess the safety, mechanism of action, and preliminary efficacy of rituximab
followed by belimumab in the treatment of refractory lupus nephritis (LN). Methods In a …

The scavenger receptor SCARF1 mediates the clearance of apoptotic cells and prevents autoimmunity

ZG Ramirez-Ortiz, WF Pendergraft III, A Prasad… - Nature …, 2013 - nature.com
The clearance of apoptotic cells is critical for the control of tissue homeostasis; however, the
full range of receptors on phagocytes responsible for the recognition of apoptotic cells …

Long-term maintenance therapy using rituximab-induced continuous B-cell depletion in patients with ANCA vasculitis

WF Pendergraft III, FB Cortazar, J Wenger… - Clinical Journal of the …, 2014 - journals.lww.com
Results In the study, 172 patients (mean age= 60 years, 55% women, 57% myeloperoxidase–
ANCA) treated from April of 2006 to March of 2013 underwent continuous B-cell depletion …

Defining glomerular disease in mechanistic terms: implementing an integrative biology approach in nephrology

LH Mariani, WF Pendergraft III… - Clinical Journal of the …, 2016 - journals.lww.com
Advances in biomedical research allow for the capture of an unprecedented level of genetic,
molecular, and clinical information from large patient cohorts, where the quest for precision …

Effect of continuous B cell depletion with rituximab on pathogenic autoantibodies and total IgG levels in antineutrophil cytoplasmic antibody–associated vasculitis

FB Cortazar, WF Pendergraft III, J Wenger… - Arthritis & …, 2017 - Wiley Online Library
Objective To evaluate the effect of rituximab on pathogenic autoantibodies and total Ig
levels, and to identify serious adverse events in patients with antineutrophil cytoplasmic …