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223 Serum 25-hydroxyvitamin d3 levels and clinical course of systemic lupus erythematosus : a cross sectional retrospective cohort study in a referral centre
  1. M Mohd Noh1,2,
  2. DM Suahilai2,
  3. NS Shahril2 and
  4. SA Alias3
  1. 1University Malaysia Sabah, Faculty Of Medicine andAllied Health Sciences, Kajang, Malaysia
  2. 2Hospital Putrajaya, Medicine, Putrayaja, Malaysia
  3. 3Hospital Putrajaya, Medical, Putrajaya, Malaysia

Abstract

Background and aims To study the association between serum 25-Hydroxyvitamin D3 levels and clinical manifestation, disease activity, and disease damage of systemic lupus erythematosus (SLE).

Methods This was a retrospective cross sectional study of SLE patients seen between 1996 until 2015. Patients were grouped according to the Vitamin D3 levels : group 1 (<25 nmol/L : deficiency), group 2 (25–75 nmol/L : insufficiency) and group 3 (>75 nmol/L : adequate). Assessment of disease activity was done using Systemic Lupus Erythematosus Disease Activity Index Selena Modification (SLEDAI) while Systemic Lupus International Collaborating Clinics (SLICC) was use for disease damage.

Results A total of 42 patients had their serum 25-Hydroxyvitamin D3 levels taken at one point of their visit. Majority were females (n=41). Mean age was 37.2 years (SD ±13.13) and mean duration of illness 9.5 years (SD ±5.7). The proportion of patients with 25-Hydroxyvitamin D3 level group 1 was 31%, group 2 was 61.9% and group 3 was 7.1% respectively. Main clinical manifestations were haematological 71.1%, arthritis 68.9%, malar rash 53.3%. SLEDAI mild activity (0-3) 90.5%, moderate activity (4-8) was 4.8% and severe activity (>8) was 4.8%. SLICC showed 78.6% had no damage and 21.4% with damage. Test of association using ANOVA, did not show any significance between Vitamin D3 level and SLEDAI, SLICC and clinical manifestations were observed among the group.

Conclusions Vitamin D insufficiency and deficiency was common in our SLE cohort.However, we did not find significant association between vitamin D deficiency and disease activity, damage or clinical manifestations. The study limitation includes small number of patients and retrospective design.

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