Article Text

PDF

435 Disease activity patterns among filipino patients with systemic lupus erythematosus: a 3-year observational study
  1. MFJ Edar,
  2. L Zamora and
  3. S Navarra
  1. University of Santo Tomas, Internal Medicine, Manila, Philippines

Abstract

Background and aims To describe organ involvement, disease activity patterns, and damage characteristics in a cohort of Filipino patients with systemic lupus erythematosus (SLE), observed over 3 years.

Methods Consenting SLE patients at University of Santo Tomas (UST) Hospital with minimum 3 visits/year were assessed over 3 years until July 2016. Disease activity patterns included clinically quiescent disease (CQD; SLEDAI=0 in 3 visits); minimal persistent disease (MDA; SLEDAI=1 in >1 visit); relapsing remitting disease (RRD; SLEDAI ≥2 in 1 of 3 visits); chronic active disease (CAD; SLEDAI ≥2 in at least 2 of 3 visits). SLICC Damage Index (SDI) characteristics were correlated with steroid use.

Results 127 SLE patients (117, 92% females), mean 28.81+10.14 SD (range 4–57) age at diagnosis, mean 7.94+5.61 SD (range 1–25) years disease duration. Organ involvement included mucocutaneous (121,95%), musculoskeletal (113, 89%) and renal (87, 68.5%). At 1 year there were 48 (40.7%) patients with CAD, 37 (31.4%) CQD, 30 (25.4%) RRD, 3 (2.5%) MDA. At 3 years, CAD patients totaled 23 (19.5%), CQD 59 (50%). Table 1 Mean cumulative prednisone dose was 21.42+17.63 at initial damage involvement. Cataract was most common SDI (26, 20.5%), significantly correlated with cumulative steroid, p<0.01. There were 131 flares in 87 patients, including 73 (56%) renal flares. Eleven patients died during the 3 year observation period.

Abstract 435 Table 1

Evolution of disease activity patterns from 1 to 3 years.

Conclusions This study reflects improvement in disease patterns among patients participating in an observational cohort study. Damage is largely driven by high cumulative steroid use.

Statistics from Altmetric.com

Request permissions

If you wish to reuse any or all of this article please use the link below which will take you to the Copyright Clearance Center’s RightsLink service. You will be able to get a quick price and instant permission to reuse the content in many different ways.