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LO-010 Relationship between the EULAR/ACR classification criteria and organ damage in systemic lupus erythematosus
  1. Chi-Chiu Mok1,
  2. Yuen Kwan Chung2,
  3. Carolyn Lee2,
  4. Ling Yin Ho1 and
  5. Chi Hung To2
  1. 1Medicine, Tuen Mun Hospital, Hong Kong
  2. 2Medicine, Pok Oi Hospital, Hong Kong


Background To study the relationship between the 2019 EULAR/ACR classification criteria and organ damage in patients with SLE

Methods Patients involved in a cross-sectional validation study of the EULAR/ACR criteria and judged by a panel to be clinical SLE were studied. Those who fulfilled the EULAR/ACR criteria (last visit) were stratified into 2 groups based on a cut-off score of 20. The last SLICC organ damage index (SDI) was compared between these two groups. Relationship among the domains of the EULAR/ACR criteria and SDI in all patients was studied by Spearman’s rank correlation.

Results 562 SLE patients were studied (93.6% women; age 36.5±14.1 years; disease duration 11.6±6.6 years). The mean and median EULAR/ACR criteria scores in those fulfilling the EULAR/ACR criteria (N=542) was 24.6±7.3 and 24 (IQR 19–30), respectively. 392 patients had EULAR/ACR scores of ≥20 (group 1) and 150 patients had scores of 10–19 (group 2). Group 1 had significantly higher prevalence of fever, alopecia, oral ulcers, acute lupus skin lesions, arthritis, serositis, seizure, hemolytic anemia, leukopenia and renal disease, and so were the anti-dsDNA, anti-Sm, antiphospholipid antibodies and low complement state. Organ damage (SDI score of ≥1) occurred in 232 (42.8%) patients. Patients in group 1 had significantly higher SDI scores in the renal, cardiovascular, dermatological and gonadal domains than group 2. The renal, neuropsychiatric and aPL antibodies domain scores of the EULAR/ACR criteria correlated positively with the total SDI. The renal domain of the EULAR/ACR criteria had the strongest correlation with renal damage (Rho 0.30; p<0.001). Patients who scored 10 points in the renal domain had significantly higher renal damage score than those scored 8 points or 4

Conclusions In addition to disease classification, the EULAR/ACR SLE criteria may have a role in.

  • lupus
  • damage
  • criteria

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