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Abstract
Background To investigate the dietary patterns and life-styles of patients with lupus gastrointestinal (GI) involvement and the possible role of diet in the organ-specific involvement of systemic lupus erythematosus (SLE).
Methods Patients with SLE complicated with gastrointestinal involvement (SLE-GI) admitted to the Peking Union Medical College Hospital (PUMCH), as well as the corresponding healthy people with age- and sex-matched as control from January 2010 to September 2021 were enrolled and matched at a ratio of 1:2. A questionnaire survey was distributed to the patients and healthy controls (HC) to collect dietary and lifestyle information.
Results The questionnaire survey results showed the SLE-GI group had a higher proportion of vegetarians (p=0.014), traditional Chinese medicine (TCM) (p=0.018) taken, and less in fried/pickled food (p=0.042), dietary supplements (p=0.024) than in the HC group. Ten patients (10/24, 41.7%) in the SLE-GI group and 7 (7/48, 14.6%) in the HC group had reported undergone surgery (p=0.014).
Conclusions The dietary patterns, life-styles, medication history of SLE-GI patients differed greatly from those of healthy control people. These factors may integrate and contribute to the susceptibility of autoimmunity and the predilection of gastrointestinal involvement in SLE.
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