Background To investigate the dietary patterns and life-styles of patients with lupus gastrointestinal (GI) involvement and the possible role of diet in the organ-specific involvement of systemic lupus erythematosus (SLE).
Methods Patients with SLE complicated with gastrointestinal involvement (SLE-GI) admitted to the Peking Union Medical College Hospital (PUMCH), as well as the corresponding healthy people with age- and sex-matched as control from January 2010 to September 2021 were enrolled and matched at a ratio of 1:2. A questionnaire survey was distributed to the patients and healthy controls (HC) to collect dietary and lifestyle information.
Results The questionnaire survey results showed the SLE-GI group had a higher proportion of vegetarians (p=0.014), traditional Chinese medicine (TCM) (p=0.018) taken, and less in fried/pickled food (p=0.042), dietary supplements (p=0.024) than in the HC group. Ten patients (10/24, 41.7%) in the SLE-GI group and 7 (7/48, 14.6%) in the HC group had reported undergone surgery (p=0.014).
Conclusions The dietary patterns, life-styles, medication history of SLE-GI patients differed greatly from those of healthy control people. These factors may integrate and contribute to the susceptibility of autoimmunity and the predilection of gastrointestinal involvement in SLE.
This is an open access article distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited, appropriate credit is given, any changes made indicated, and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/.
Statistics from Altmetric.com
If you wish to reuse any or all of this article please use the link below which will take you to the Copyright Clearance Center’s RightsLink service. You will be able to get a quick price and instant permission to reuse the content in many different ways.