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LP-171 Fibromyalgia and glucocorticoids use drives self-perceived depression in systemic lupus erythematosus: insights from a large prospective and multicenter study using Relesserpros register’s database.
  1. Iñigo Rúa-Figueroa1,
  2. Julia Martínez-Barrio2,
  3. Norman Jiménez3,
  4. María Galindo-Izquierdo4,
  5. Esther Uriarte-Isacelaya5,
  6. Antonio Fernandez-Nebro6,
  7. Jaime Calvo7,
  8. Sara Manrique-Arija6,
  9. Jose Rosas8,
  10. Rocio Caño-Alameda9,
  11. J. Narváez10,
  12. Inmaculada Ros11,
  13. Elena Aurrecoechea12,
  14. Vicenç Torrente-Segarra13,
  15. Clara Sanguesa14,
  16. Mercedes Freire-González15,
  17. Eva Tomero-Muriel16,
  18. Loreto Horcada17,
  19. Clara Moriano18,
  20. Mireia Moreno19,
  21. Carlota Laura-Iñíguez20,
  22. Ricardo Blanco21,
  23. Ana Pérez-Gómez22,
  24. José Luis Andréu-Sánchez23,
  25. Sandra Garrote-Corral24,
  26. Santiago Muñoz-Fernández25,
  27. Gema Bonilla26,
  28. Nuria Lozano-Rivas27,
  29. Carlos A Montilla-Morales28,
  30. O Ibarguengoitia29,
  31. Lorena Expósito30,
  32. Elia Vals-Pascual31,
  33. Angela Pecondon-Español32,
  34. Sergio Machín33,
  35. Eva Salgado-Perez34,
  36. Maria Celia-Erausquin1,
  37. Tarek Carlos Salman-Monte35,
  38. Raúl Menor-Almagro36,
  39. Alejandro Muñoz-Jimenez37,
  40. Irene Altabás-González38,
  41. Jorge Juan Fragío-Gil39 and
  42. Jose María Pego-Reigosa38
  1. 1Rheumatology, Hospital De Gran Canaria Doctor Negrin, Spain
  2. 2Rheumatology, Hospital Gregorio Marañón, Spain
  3. 3Rheumatology, Instituto De Investigación Sanitaria Galicia Sur, IRIDIS Group, Spain
  4. 4Rheumatology, University Hospital October 12, Spain
  5. 5Rheumatology, Donostia Unibertsitate Ospitalea, Spain
  6. 6Rheumatology, Hospital Regional Universitario de Málaga, Spain
  7. 7Rheumatology, Araba University Hospital, Spain
  8. 8Rheumatology, Hospital Marina Baixa, Spain
  9. 9Rheumatology, General University Hospital of Alicantet, Spain
  10. 10Rheumatology, Bellvitge University Hospital, Spain
  11. 11Rheumatology, Son Llàtzer Hospital, Spain
  12. 12Rheumatology, Hospital Sierra Llana, Spain
  13. 13Rheumatology, Hospital de Sant Joan Despí Moisès Broggi, Spain
  14. 14Rheumatology, Germans Trias i Pujol Hospital, Spain
  15. 15Rheumatology, University Hospital of A Coruña, Spain
  16. 16Rheumatology, Hospital de La Princesa, Spain
  17. 17Rheumatology, Navarra Hospital Complex, Spain
  18. 18Rheumatology, University Hospital of León, Spain
  19. 19Rheumatology, Hospital Parc Taulí de Sabadell, Spain
  20. 20Rheumatology, Hospital Lugo, Spain
  21. 21Rheumatology, Marqués de Valdecilla University Hospital, Spain
  22. 22Rheumatology, Hospital Universitario Príncipe De Asturias, Spain
  23. 23Rheumatology, Puerta de Hierro Majadahonda University Hospital, Spain
  24. 24Rheumatology, Ramón y Caja Hospital, Spain
  25. 25Rheumatology, Infanta Sofia University Hospital, Spain
  26. 26Rheumatology, La Paz University Hospital, Spain
  27. 27Rheumatology, Hospital Clínico Universitario Virgen de la Arrixaca, Spain
  28. 28Rheumatology, Salamanca University Hospital, Spain
  29. 29Rheumatology, Basurto University Hospital, Spain
  30. 30Rheumatology, Hospital Universitario De Canarias, Spain
  31. 31Rheumatology, Doctor Peset University Hospital, Spain
  32. 32Rheumatology, Miguel Servet University Hospital, Spain
  33. 33Rheumatology, Hospital Materno Infantil De Gran Canaria, Spain
  34. 34Rheumatology, Complexo Hospitalario Universitario De Ourense, Spain
  35. 35Rheumatology, Hospital Del Mar, Spain
  36. 36Rheumatology, Hospital Universitario De Jerez, Spain
  37. 37Rheumatology, Virgen Del Rocío University Hospital, Spain
  38. 38Rheumatology, Complejo Hospitalario Universitario De Vigo, Spain
  39. 39Rheumatology, La Fe University and Polytechnic Hospital, Spain


Background Little is known about depression in SLE. To evaluate the prevalence of depression and associated factors in a large, multicenter SLE cohort (RELESSER-PROS).

Methods Prospective longitudinal study of SLE patients answering positively to the depression question of the Lupus Impact Tracker (LIT) questionary (question number 7, LITQ7 ‘I was depressed’) over 5 consecutive annual visits (V1 to V5). Self-perceived depression was answered from 0 (‘none of the time’) to 4 (‘most of time’). Covariates with potential impact in depression were considered. Friedman test and GEE models were used.

Results 1463 patients were included. Mean age 55 years, 90% female. Mean disease duration: 14 years. Fibromyalgia was present in 5.7%. Glucocorticoids use ranged from 49.4% to 57%, depending on the visit. SLEDAI ranged from 0 to 2 and SDI from 1 to 2. Prevalence of ‘depression any time’ was 89.9% and ‘most of time’ in 34.6%. Up to 26.5% answered to LITQ7 ‘depression most of time’ in the five visits. 89.7% perceived themselves as depressed at least in 2 out of 5 visits. Only 6.9% of the patients with previous diagnosis of depression answered ‘0’ (‘none of the time’) to LITQ7. SLEDAI, SDI, Charlson and glucocorticoids use showed statistically significative changes during the follow up. Patients with ‘depression any time’ developed more damage at V5 than patients without depression (p=0.009). In the GEE binomial analysis, fibromyalgia (OR 2.79), unemployment (OR 1.95) and glucocorticoids use (OR 1.88) were significantly associated with ‘depression any time’. The best model displayed a significant association with fibromyalgia (OR 2.90) and glucocorticoids (OR 1.85). Neither SDI nor unemployment reached significance (table 1). Without entering glucocorticoids, SLEDAI turns significant in the model, suggesting collinearity.

Conclusions The prevalence of self-perceived depression is high in SLE. Our study suggests causal relationship between glucocorticoids use, fibromyalgia and self-perceived depression.

Abstract LP-171 Table 1

Best multivariable GEE model

  • SLE
  • Lupus

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