You are here

Article Text

Article menu

Download PDFPDF

Brief communication
Jaccoud’s arthropathy in SLE: findings from a Latin American multiethnic population
  1. Rosana Quintana1,
  2. Guillermo Pons-Estel1,
  3. Karen Roberts2,
  4. Monica Sacnún2,
  5. Guillermo Berbotto3,
  6. Mercedes A Garcia4,
  7. Veronica Saurit5,
  8. Leonor Barile-Fabris6,
  9. Eduardo M Acevedo-Vazquez7,
  10. João C Tavares Brenol8,
  11. Emilia I Sato9,
  12. Antonio Iglesias10,
  13. Oscar Uribe11,
  14. Graciela Alarcon12,13 and
  15. Bernardo A Pons-Estel1
  1. 1Department of Internal Medicine, Centro Regional de Enfermedades Autoinmunes y Reumáticas (CREAR), Rosario, Argentina
  2. 2Department of Rheumatology, Hospital Provincial de Rosario, Rosario, Argentina
  3. 3Department of Rheumatology, Hospital Escuela Eva Perón, Granadero Baigorria, Argentina
  4. 4Department of Rheumatology, Hospital Interzonal General de Agudos General San Martín, La Plata, Argentina
  5. 5Department of Rheumatology, Hospital Privado, Cordoba, Cordoba, Argentina
  6. 6Department of Rheumatology, Hospital Angeles del Pedregal, Ciudad de México, Ciudad de Mexico, Mexico
  7. 7Department of Rheumatology, Hospital Nacional Guillermo Almenara Irigoyen, ESSALUD, Lima, Peru
  8. 8Department of Rheumatology, Hospital das Clinicas de Porto Alegre, Universidade Federal do Rio Grande do Sul, Porto Alegre, Brazil
  9. 9Department of Rheumatology, Escola Paulista de Medicina, Universidade Federal de São Paulo, São Paulo, Brazil
  10. 10Department of Medicine, Universidad Nacional de Colombia, Bogota, Colombia
  11. 11Department of Rheumatology, Universidad de Antioquia, Hospital Universitario “Fundación San Vicente”, Medellin, Colombia
  12. 12Department of Medicine, Division of Clinical Immunology and Rheumatology, School of Medicine, The University of Alabama at Birmingham, Birmingham, England, USA
  13. 13Department of Medicine, Universidad Peruana Cayetano Heredia, Lima, Peru
  1. Correspondence to Dr Rosana Quintana,Internal Medicine, Centro Regional de Enfermedades Autoinmunes y Reumáticas (CREAR), Rosario, Argentina; rosanaquintana{at}gmail.com

Abstract

Objective To compare the clinical, laboratory and outcome features of SLE patients with and without Jaccoud’s arthropathy (JA) from the Grupo Latino Americano De Estudio del Lupus (GLADEL) cohort.

Methods 1480 patients with SLE [(34 centres, 9 Latin American countries with a recent diagnosis (≤2 years)] constitute the GLADEL cohort. JA was defined as reducible deformity of the metacarpophalangeal axis, without radiographic erosions at any time. Within this cohort, a nested case–control study was carried out. Control was matched for age, gender and centre in a 1:3 proportion. The variables included were: sociodemographic, clinical and immunological features, disease activity, damage and mortality. Comparisons were performed with Wilcoxon and χ2 tests for continuous and categorical variables, respectively. ORs and 95% CIs and Kaplan-Meier survival curve were estimated.

Results Of 1480 patients, 17 (1.1%) JA patients were identified; 16 (94.1%) of them were women, mean age: 31.0 years (SD 12.0). Five (29.4%) patients presented JA at SLE diagnosis and 12 (70.6%) after. The median follow-up time and all disease features were comparable in both groups except for a higher frequency of pneumonitis in the patients with JA [4 (23.5) vs 1 (2.0); p=0.012; (OR: 15.4; 95% CI 1.6 to 149.6)]. The SLE disease activity index, Systemic Lupus International Collaborating Clinics/American College of Rheumatology damage Index and the Kaplan-Meier survival curve were similar in both groups.

Conclusion JA may tend to appear early in the course of SLE; it seems not to have an impact on disease activity, damage accrual or in survival.

  • Systemic lupus erythematosus
  • Jaccoud’s arthropathy
  • deforming arthropathy
  • disease activity
  • mortality

This is an open access article distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited, appropriate credit is given, any changes made indicated, and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/.

https://doi.org/10.1136/lupus-2019-000343

Statistics from Altmetric.com

    Request Permissions

    If you wish to reuse any or all of this article please use the link below which will take you to the Copyright Clearance Center’s RightsLink service. You will be able to get a quick price and instant permission to reuse the content in many different ways.

    View Full Text

    Footnotes

    • Contributors All authors were involved in drafting or revising this article critically for important intellectual content, and all authors approved the final version to be published. RQ, GP-E, GA and BAP-E have full access to all of the data from the study and take responsibility for their integrity and the accuracy of the analyses performed.

    • Funding The authors have not declared a specific grant for this research from any funding agency in the public, commercial or not-for-profit sectors.

    • Competing interests None declared.

    • Patient consent for publication Not required.

    • Provenance and peer review Not commissioned; externally peer reviewed.