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  • PO.1.21 Attainment of EQ-5D-3L full health state after therapy is associated with decelerated organ damage accrual in systemic lupus erythematosus

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Thursday 06 October 2022 from 13:00 to 14:10
Po.1 E- poster session 1: animal models, omics in lupus, major organ involvement inclucing npsle, organ damage and survival
PO.1.21 Attainment of EQ-5D-3L full health state after therapy is associated with decelerated organ damage accrual in systemic lupus erythematosus
  1. J Lindblom1,
  2. S Zetterberg1,
  3. A Borg1,
  4. S Emamikia1,
  5. G Von Perner2,
  6. Y Enman1,
  7. E Heintz3,
  8. M Regardt4,
  9. D Grannas5,
  10. A Gomez1 and
  11. I Parodis1
  1. 1Division of Rheumatology, Department of Medicine Solna, Karolinska Institutet and Karolinska University Hospital ~ Stockholm ~ Sweden
  2. 2Swedish Rheumatism Association ~ Stockholm ~ Sweden
  3. 3Department of Learning, Informatics, Management and Ethics (LIME), Karolinska Institutet ~ Stockholm ~ Sweden
  4. 4Occupational Therapy and Physiotherapy, Karolinska University Hospital ~ Stockholm ~ Sweden
  5. 5Division of Biostatistics, Institute of Environmental Medicine, Karolinska Institutet ~ Stockholm ~ Sweden

Abstract

Purpose Within the frame of a survey of the impact of patient-reported evaluation on long-term outcomes in systemic lupus erythematosus (SLE), we herein investigated whether attainment of self-reported full health state (FHS) following therapeutic intervention for active disease was associated with a lower probability to accrue organ damage.

Methods Data from the open-label (OL) extension periods of the BLISS-52 and BLISS-76 clinical trials of belimumab in SLE were used (N=973). FHS was defined as an experience of ‘no problems’ in all five dimensions of the EuroQol 5-Dimension health questionnaire three-level version (EQ-5D-3L). We also investigated potential associations between experience of ‘no problems’ in each one of the EQ-5D dimensions and organ damage accrual separately. Proportional hazards (Cox) regression analysis was employed for time-dependent associations between EQ-5D-3L responses at the OL baseline and the first documented increase in organ damage, as assessed using the Systemic Lupus International Collaborating Clinics (SLICC)/American College of Rheumatology (ACR) Damage Index (SDI).

Results FHS was associated with lower probability of and/or longer time to organ damage progression (adj. HR: 0.62; 95% CI: 0.38–0.99; P=0.047) after adjustment for potential confounders, as was experience of ’no problems’ regarding mobility (adj. HR: 0.61; 95% CI: 0.43–0.87; P=0.006) and pain/discomfort (HR: 0.66; 95% CI: 0.44–1.00; P=0.049). No such association was seen in multivariable analyses for the other dimensions of EQ-5D; however, ‘no problems’ with regard to self-care showed a trend towards a statistically significant association with decelerated organ damage accrual (adj. HR: 0.65; 95% CI: 0.42–1.01; P=0.054).

Conclusions Experience of FHS and ‘no problems’ regarding mobility or pain/discomfort after therapeutic intervention for active SLE were associated with reduced subsequent risk of organ damage accrual, suggesting that optimisation of these health-related quality of life (HRQoL) aspects is a clinically relevant treatment target in patients with SLE.

http://creativecommons.org/licenses/by-nc/4.0/

This is an open access article distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited, appropriate credit is given, any changes made indicated, and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/.

https://doi.org/10.1136/lupus-2022-elm2022.52

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